Oleic Acid

(USAN, rINN)
Oleic Acid Chemical formula
Synonyms: Acide oléique; Acidum oleicum; Elaic Acid; Kwas oleinowy; Kyselina olejová; Olajsav; Oleico, ácido; Oleinic Acid; Oleino ru _ gštis; Oljesyra; Öljyhappo; Ölsäure. (Z)-9-Octadecanoic acid.
Cyrillic synonym: Масляная Кислота; Олеиновая Кислота.

💊 Chemical information

Chemical formula: C18H34O2 = 282.5.
CAS — 112-80-1.

Pharmacopoeias.

In Eur.. Also in USNF.

Ph. Eur. 6.2

(Oleic Acid). It contains 65 to 88% of oleic acid together with varying amounts of saturated and other unsaturated fatty acids. It may contain a suitable antoxidant. It is a clear, yellowish or brownish, oily liquid. Practically insoluble in water; miscible with alcohol and with dichloromethane. Store in wellfilled airtight containers. Protect from light.

USNF 26

(Oleic Acid). It is manufactured from fats and oils derived from edible sources, animal or vegetable, and consists chiefly of oleic acid. It may contain suitable stabilisers. Oleic acid solely for external use is exempt from the requirement that it be prepared from edible sources. It is a colourless to pale yellow oily liquid when freshly prepared with a characteristic lardlike odour. On exposure to air it gradually absorbs oxygen and darkens in colour. When strongly heated in air, it is decomposed with the production of acid vapours. Congealing point between 3° and 10° for oleic acid from animal sources and between 10° and 16° for oleic acid from vegetable sources. Practically insoluble in water; miscible with alcohol, with chloroform, with ether, with benzene and with fixed and volatile oils. Store in airtight containers.

💊 Profile

Oleic acid forms soaps with alkaline substances and is used as an emulsifying or solubilising agent. It occurs in edible fats and oils which are used as foods or food components. Oleic acid is used in topical preparations, including transdermal films and patches, and in oral and inhalation preparations. It has also been used as a choleretic.

💊 Preparations

BP 2008: Chloroxylenol Solution; White Liniment. Proprietary PreparationsMulti-ingredient: Braz.: Glavit; Primoris; Chile: Acnoxyl Jabon†.
Published November 03, 2018.