Dinoprost Trometamol

(BANM, rINNM)
Synonyms: Dinoprost trométamol; Dinoprost Tromethamine (USAN); Dinoprostas trometamolis; Dinoprostitrometamoli; Dinoprosttrometamol; Dinoprost-trometamol; Dinoprostum Trometamoli; Dinoprostum trometamolum; Dinoproszt-trometamol; PGF 2 THAM; Prostaglandin F 2 Trometamol; U-14583E.
Cyrillic synonym: Динопрост Трометамол.

💊 Chemical information

Chemical formula: C20H34O5,C4H11NO3 = 475.6.
CAS — 38562-01-5.
ATC — G02AD01.
ATC Vet — QG02AD01.

Pharmacopoeias.

In Eur. and US.

Ph. Eur. 6.2

(Dinoprost Trometamol). A white or almost white powder. Very soluble in water; freely soluble in alcohol; practically insoluble in acetonitrile.

USP 31

(Dinoprost Tromethamine). A white to off-white crystalline powder. Very soluble in water; slightly soluble in chloroform; freely soluble in dimethylformamide; soluble in methyl alcohol. Store in airtight containers.

💊 Adverse Effects and Precautions

As for Dinoprostone. Dinoprost can cause bronchoconstriction, and bronchospasm with wheezing and dyspnoea has occurred, especially in asthmatic patients. Once a prostaglandin has been given to terminate pregnancy it is essential that termination take place; if the prostaglandin is unsuccessful other measures should be used.

💊 Interactions

As for Dinoprostone. Alcohol and beta agonists may reduce the efficacy of dinoprost.

💊 Uses and Administration

Dinoprost is a prostaglandin of the F series with actions on smooth muscle; the endogenous substance is termed prostaglandin F2 and is rapidly metabolised in the body. It induces contraction of uterine muscle at any stage of pregnancy and is reported to act mainly as a vasoconstrictor on blood vessels and as a bronchoconstrictor on bronchial muscle. Dinoprost is used principally for the termination of pregnancy. It may also be used for missed abortion, hydatidiform mole, and intra-uterine fetal death. Dinoprost is usually given intra-amniotically for termination of pregnancy. It has been given intravenously, but with a high incidence of adverse effects. The extra-amniotic route has also been used. Dinoprost is given as the trometamol salt, but doses are described in terms of the base; 1.3 mg of dinoprost trometamol is equivalent to about 1 mg of dinoprost. For the termination of pregnancy during the second trimester 40 mg of dinoprost is given intra-amniotically by slowly injecting 8 mL of a solution containing 5 mg/mL into the amniotic sac. A further dose of 10 to 40 mg may be given after 24 hours if the termination process has not been established or completed and the membranes are still intact. It should not be given continuously for more than 2 days.

Ileus.

Ileus induced by vinca alkaloids in 3 patients with carcinoma of the lung was successfully relieved by the intravenous infusion of dinoprost 300 to 500 nanograms/kg per minute for 2 hours twice daily.1
1. Saito H, et al. Prostaglandin F in the treatment of vinca alkaloid-induced ileus. Am J Med 1993; 95: 549–51.

💊 Preparations

Proprietary Preparations

Austral.: Prostin F2 Alpha; Cz.: Enzaprost F; Ger.: Minprostin F α; Gr.: Enzaprost; Hong Kong: Prostin F2 Alpha; Hung.: Enzaprost F; Irl.: Prostin F2†; Israel: Prostin F2 Alpha; NZ: Prostin F2 Alpha; Pol.: Enzaprost; Rus.: Enzaprost F (Энзапрост Ф); Prostin F2 Alfa (Простин F2-Альфа)†; S.Afr.: Prostin F2 Alpha.
Published October 22, 2018.