Sodium Ferric Gluconate Complex

(USAN)

💊 Chemical information

Ferric Sodium Gluconate; D-Gluconic acid, iron (3+) sodium salt; Hierro gluconato sódico, complejo de; Iron Gluconate; Natrii ferrigluconas; Sodium Ferric Gluconate; Sodium ferrigluconate; Sodium-Iron(III) Gluconate Complex.
Chemical formula: [NaFe2O3(C6H11O7)(C12H22O11)5] x .
CAS — 34089-81-1.
ATC Vet — QB03AC07.
NOTE. Distinguish from Ferrous Gluconate.

💊 Adverse Effects, Treatment, and Precautions

For parenteral iron, see Iron Dextran.

Hypersensitivity.

For a discussion as to whether sodium ferric gluconate complex may be a safer alternative to iron dextran.

💊 Pharmacokinetics

Peak concentrations vary with the dose and rate at which sodium ferric gluconate complex is given. The volume of distribution does not appear to vary according to dose or rate. Elimination half-life varies by dose, and has been reported to be 0.85 hours for a dose of 62.5 mg and 1.45 hours for a dose of 125 mg; doses were given by slow intravenous injection.

💊 Uses and Administration

Sodium ferric gluconate complex is used as a source of iron for iron-deficiency anaemia. It is given as a solution containing the equivalent of 12.5 mg/mL of elemental iron. The recommended dose for haemodialysis patients who are receiving epoetin therapy is 125 mg iron (10 mL) diluted in 100 mL sodium chloride 0.9%, and given as an intravenous infusion over 1 hour; it may also be given undiluted as a slow intravenous injection (at a rate of 12.5 mg/minute) during dialysis. This dose is usually repeated over 8 dialysis sessions to achieve a favourable response. Children 6 years of age and older may be given 1.5 mg/kg of elemental iron (0.12 mL/kg), diluted in 25 mL sodium chloride 0.9% and infused over 1 hour, up to a maximum of 125 mg per dose.

Anaemia of chronic renal failure.

References.
1. Yorgin PD, et al. Sodium ferric gluconate therapy in renal transplant and renal failure patients. Pediatr Nephrol 2000; 15: 171–5
2. Fishbane S, Wagner J. Sodium ferric gluconate complex in the treatment of iron deficiency for patients on dialysis. Am J Kidney Dis 2001; 37: 879–83
3. Folkert VW, et al. Chronic use of sodium ferric gluconate complex in hemodialysis patients: safety of higher dose (> or =250 mg) administration. Am J Kidney Dis 2003; 41: 651–7
4. Michael B, et al. Sodium ferric gluconate complex in haemodialysis patients: a prospective evaluation of long-term safety. Nephrol Dial Transplant 2004; 19: 1576–80.

💊 Preparations

Proprietary Preparations

Chile: Pentaferr; Cz.: Ferrlecit; Ger.: Ferrlecit; Hung.: Ferrlecit; India: Efecient; Israel: Ferrlecit; Ital.: Actiferro†; Epaplex 40†; Extrafer; Ferlixit; FerriEmina†; Ferritin Oti; Ferrosprint; Fevital Simplex†; Hemocromo; Inferil†; Rossepar; Rubroferrina†; Sanifer; USA: Ferrlecit. Multi-ingredient: Ital.: Ferritin Complex; Port.: Ferritin Oti.
Published January 25, 2019.