Magnesium Oxide

(BAN)
Synonyms: E530; Magnesii oxidum; Magnesio, óxido de; Magnésium, oxyde de; Magnesiumoksidi; Magnesiumoxid; Magnezu tlenek; Magnezyum Oksit; Magnio oksidas; Nehéz magnézium; Oxid hořečnatý.
Cyrillic synonym: Магния Оксид.

💊 Chemical information

MgO = 40.30.
CAS — 1309-48-4.
ATC — A02AA02; A06AD02; A12CC10. ATC Vet — QA02AA02; QA06AD02; QA12CC10.

Pharmacopoeias.

In Chin., Eur., Int., Jpn, US, and Viet. Some pharmacopoeias include a single monograph that permits both the light and heavy varieties while some have 2 separate monographs for the 2 varieties.

Ph. Eur. 6.2 (Magnesium Oxide, Heavy; Magnesii Oxidum Ponderosum). A fine, white or almost white powder. 15 g has an apparent volume before settling of not more than 60 mL. Practically insoluble in water; dissolves in dilute acids with at most slight effervescence.

Ph. Eur. 6.2 (Magnesium Oxide, Light; Magnesii Oxidum Leve). A fine, white or almost white, amorphous powder. 15 g has an apparent volume before settling of at least 100 mL. Practically insoluble in water; dissolves in dilute acids with at most slight effervescence.

USP 31

(Magnesium Oxide). A very bulky, white powder, or a relatively dense, white powder, or a granulated powder. Practically insoluble in water; insoluble in alcohol; soluble in dilute acids. Store in airtight containers.

💊 Profile

Magnesium oxide is an antacid with general properties similar to those of magnesium hydroxide (above). It is given in usual oral doses of about 400 mg. It is often given with aluminium-containing antacids such as aluminium hydroxide, which counteract its laxative effect. Magnesium oxide has been used for its osmotic laxative properties in bowel preparation; oral doses of 3.5 g are given for this purpose, combined with bisacodyl or sodium picosulfate. Magnesium oxide is also used as a magnesium supplement in deficiency states in oral doses of up to 800 mg (20 mmol) daily. It is also used as a food additive.

💊 Preparations

USP 31: Alumina, Magnesium Carbonate, and Magnesium Oxide Tablets; Aromatic Cascara Fluidextract; Aspirin, Alumina, and Magnesium Oxide Tablets; Citric Acid, Magnesium Oxide, and Sodium Carbonate Irrigation; Magnesium Oxide Capsules; Magnesium Oxide Tablets.

Proprietary Preparations

Arg.: Magneforte†; Polvo Roge; SG 33; Austria: Magnonorm; Magnotab; Denm.: Salilax; Fr.: Mag 2 Junior; Magocean; Sargemag; Thalamag; Ger.: Biolectra Magnesium 240; Biolectra Magnesium 365; Magium; Magnesium Diasporal; Magnesium Tonil; Magnetrans extra; Magnetrans forte; Magno Sanol; Hung.: Magnosolv; NZ: Mylanta Effervescent†; S.Afr.: Solumag; Swed.: Salilax; Thai.: Magoral; Turk.: Magnezi Kalsine; USA: Mag-200; Mag-Caps; Mag-Ox; Maox; Uro-Mag. Used as an adjunct in: Arg.: Aspirina; Bufferin†; Braz.: Bufferin; Canad.: Aspirin with Stomach Guard; Bufferin; Tri-Buffered ASA; Ital.: Bufferin†; Pol.: Aspimag; Cardiofil; USA: Adprin-B; Bufferin; Cama Arthritis Pain Reliever; Extra Strength Bayer Plus.
Published January 27, 2019.