Kaolin

(rINNM)
Synonyms: Bolus Alba; Caolín; E559; Kaoliini; Kaolinas; Kaolinum; Weisser To n .
Cyrillic synonym: Каолин.

💊 Chemical information

CAS — 1332-58-7.
ATC — A07BC02.
ATC Vet — QA07BC02.

Pharmacopoeias.

In Chin., Eur., Int., Jpn, US, and Viet. Some pharmacopoeias do not differentiate between the heavy and light varieties.

Ph. Eur. 6.2

(Kaolin, Heavy). A purified, natural, hydrated aluminium silicate of variable composition. It is a fine, white or greyish-white, unctuous powder. Practically insoluble in water and in organic solvents.

BP 2008 (Light Kaolin). A native hydrated aluminium silicate, freed from most of its impurities by elutriation, and dried. It contains a suitable dispersing agent. It is a light, white, odourless or almost odourless, unctuous powder free from gritty particles. Practically insoluble in water and in mineral acids. The

BP 2008 directs that when Kaolin or Light Kaolin is prescribed or demanded, Light Kaolin shall be dispensed or supplied, unless it is ascertained that Light Kaolin (Natural) is required.

BP 2008 (Light Kaolin (Natural)). It is Light Kaolin which does not contain a dispersing agent. It is a light, white, odourless or almost odourless, unctuous powder free from gritty particles. Practically insoluble in water and in mineral acids. The

BP 2008 directs that when Kaolin or Light Kaolin is prescribed or demanded, Light Kaolin shall be dispensed or supplied, unless it is ascertained that Light Kaolin (Natural) is required.

USP 31

(Kaolin). A native hydrated aluminium silicate, powdered and freed from gritty particles by elutriation. It is a soft, white or yellowish-white powder or lumps with an earthy or clay-like taste and when moistened with water assumes a darker colour and develops a marked clay-like odour. Insoluble in water, in cold dilute acids, and in solutions of alkali hydroxides.

💊 Profile

Light kaolin and light kaolin (natural) are adsorbent antidiarrhoeal agents that have been used as adjuncts to rehydration therapy in the management of diarrhoea. Up to about 24 g daily may be taken orally in divided doses. Kaolin is often combined with other antidiarrhoeals, especially pectin. Kaolin can form insoluble complexes with some drugs in the gastrointestinal tract and reduce their absorption; oral doses should not be taken at the same time. Externally, light kaolin is used as a dusting powder. Kaolin is liable to be heavily contaminated with bacteria, and when used in dusting powders, it should be sterilised. Heavy kaolin is used in the preparation of kaolin poultice, which is applied topically with the intention of reducing inflammation and alleviating pain. Light kaolin is also used as a food additive.

💊 Preparations

BP 2008: Kaolin and Morphine Mixture; Kaolin Mixture; Kaolin Poultice.

Proprietary Preparations

Braz.: Kaogel†; UK: Childrens Diarrhoea Mixture; Entrocalm. Multi-ingredient: Arg.: Anusol-A; Argeal; Endomicina†; Gastranil†; Opocarbon; Opocler†; Austral.: Bis-Pectin†; Chemists Own Diarrhoea Mixture†; Diarcalm; Donnagel; Kaomagma with Pectin†; Kaomagma†; Belg.: Alopate; Neutroses; Braz.: Atalin†; Digastril†; Eviprostat†; Gastrobene; Kaomagma; Kaopectin†; Chile: Furazolidona; Fr.: Anti-H†; Antiphlogistine†; Argeal; Gastropax; Kaobrol†; Kaologeais; Kaomuth; Karayal; Keracnyl; Neutroses; Ger.: Kaoprompt-H; rohasal†; Gr.: Fissan-Pate†; Kaopectate†; Hong Kong: Calamine-D†; Uni-Kaotin; Hung.: Bolus Adstringens; Bolus Laxans; Indon.: Kaopectate; Neo Diaform; Neo Kaocitin; Neo Kaolana; Neo Kaominal; Irl.: Kaopectate†; Israel: Digestif-Ara†; Kaopectin; Kapectin Forte†; Zincod; Ital.: Katoxyn; Neutrose S Pellegrino; Streptomagma; Malaysia: Beakopectin†; Kaopectate†; Mex.: Ameban; Caopecfar; Colfur; Contefur†; Coralzul; Depofin; Dia-Par Compuesto; Dibapec Compuesto; Estibal; Exofur; Facetin-D; Farpectol; Furoxona CP; Fuzotyl†; Hidromagma†; Isocar; K-Omistron; Kaomycin; Kaopectate; Kapecfuran; Kediar; Lactopectin; Neokap; Neoxil; Olam; Optazol; Quimefuran; Suyodil; Tapzol con Neomicina†; Treda; Trilor†; Yodozona; S.Afr.: Betapect; Bipectinol; Biskapect; Bolus Eucalypti Comp; Chloropect; Collodene; Enterolyte; Gastropect; Kao†; Kaopectin†; Kaostatex; Pectin-K; Pectrolyte; SB Diarrhoea Mixture; Singapore: Beakopectin; Kaomix; Kaopectate†; Switz.: Argent†; Cicafissan; Fissan†; Gyrosan†; Neo-Decongestine; Neutroses; Padma-Lax; Padmed Laxan; Phlogantin; Thai.: Alkamine; Alumag; Alupep; Antacil†; Cenopec; Coccila†; Conmag; Di-Su-Frone†; Difuran; Disento; Disento PF; Droximag†; Furasian; Furopectin†; Kaopectal; Med-Kafuzone†; UAE: Kaptin; UK: Collis Browne’s; De Witt’s Antacid; Junior Kao-C; Kaodene†; KLN; Moorland; Opazimes; USA: K-C; Kao-Paverin; Kao-Spen; Kaodene Non-Narcotic; Mexsana; Venez.: Kaopecon†; Kaopectate†; Klincosal; Niosilin; Parepectolin†; Pec-Kao†; Sendafur†.
Published January 22, 2019.