Dantron

(BAN, rINN)
Dantron Chemical formula
Synonyms: Antrapurol; Chrysazin; Danthron; Dantrón; Dantrone; Dantroni; Dantronum; Dianthon; Dioxyanthrachinonum. 1,8-Dihydroxyanthraquinone.
Cyrillic synonym: Дантрон.

💊 Chemical information

Chemical formula: C14H8O4 = 240.2.
CAS — 117-10-2.
ATC — A06AB03.
ATC Vet — QA06AB03.

Pharmacopoeias.

In Br.

BP 2008

(Dantron). An orange, odourless or almost odourless, crystalline powder. Practically insoluble in water; very slightly soluble in alcohol; soluble in chloroform; slightly soluble in ether; dissolves in solutions of alkali hydroxides.

💊 Adverse Effects and Precautions

As for Senna. Dantron may colour the urine pink or red. Discoloration and superficial sloughing of perianal skin can occur after prolonged contact, therefore dantron should not be used in infants wearing nappies (diapers) and should be used with caution in incontinent patients. The mucosa of the large intestine may be discoloured with prolonged use or high dosage. In rodents, dantron has been associated with the development of intestinal and liver tumours. Consequently, its use has been restricted, see Uses and Administration, below. There has also been a report of intestinal sarcoma in an 18-year-old girl with a history of prolonged use of a dantroncontaining laxative.4 In May 2000 the UK CSM restricted the use of dantron to terminally ill patients on the grounds that pre-clinical evidence had increased and dantron was now established as a potential human carcinogen.5
1. Tolman KG, et al. Possible hepatotoxicity of Doxidan. Ann Intern Med 1976; 84: 290–2
2. Darke CS, Cooper RG. Unusual case of skin discoloration. BMJ 1978; 1: 1188–9
3. Greer IA. Orange periods. BMJ 1984; 289: 323
4. Patel PM, et al. Anthraquinone laxatives and human cancer: an association in one case. Postgrad Med J 1989; 65: 216–17
5. Committee on Safety of Medicines/Medicine Control Agency. Danthron restricted to constipation in the terminally ill. Current Problems 2000; 26: 4. Also available at: http:// www.mhra.gov.uk/home/idcplg?IdcService=GET_FILE& dDocName=CON007462&RevisionSelectionMethod= LatestReleased (accessed 08/11/06)

Breast feeding.

The American Academy of Pediatrics1 state that, although usually compatible with breast feeding, use of dantron by breast-feeding mothers has been reported to cause increased bowel activity in the infant.
1. American Academy of Pediatrics. The transfer of drugs and other chemicals into human milk. Pediatrics 2001; 108: 776–89. Correction. ibid.; 1029. Also available at: http://aappolicy.aappublications.org/cgi/content/full/ pediatrics%3b108/3/776 (accessed 08/11/06)

💊 Pharmacokinetics

Dantron is metabolised by bacteria in the colon. Dantron or its metabolites are absorbed from the gastrointestinal tract, as indicated by discoloration of urine in some patients. Dantron or its metabolites are excreted in the faeces and the urine, and also in other secretions including breast milk.

💊 Uses and Administration

Dantron is an anthraquinone stimulant laxative but, unlike senna, it is not a glycoside. It is given orally to treat constipation and is effective within 6 to 12 hours. However, because of concern over rodent carcinogenicity it has been withdrawn in some countries, and its use restricted in others. In the UK, it may be used only in terminally ill patients. Dantron is given in doses of 25 to 75 mg when given with poloxamer 188 as co-danthramer, and in doses of 50 to 150 mg when given with docusate sodium as co-danthrusate. Doses are usually given at bedtime. For doses in children, see below.

Administration in children.

Children under 12 years have been given dantron 12.5 to 25 mg orally as co-danthramer or 50 mg as co-danthrusate. Doses are usually given at bedtime. Children aged 12 years and over may be treated with the adult dose (see Uses and Administration, above). The BNFC recommends similar doses to these, but restricts the use of co-danthramer to children aged 2 years and over, and the use of co-danthrusate to those aged 6 years and over. Dantron should not be used in infants wearing nappies (diapers) as it may cause discoloration and superficial sloughing of the skin.

💊 Preparations

BP 2008: Co-danthrusate Capsules. Proprietary PreparationsMulti-ingredient: Braz.: Fenogar†; Chile: Modane; Irl.: Ailax; Codalax; Cotron; Mex.: Modaton; NZ: Codalax†; Conthram†; UK: Ailax†; Capsuvac; Codalax; Danlax; Normax.
Published December 25, 2018.