Cascara

(USAN)
Synonyms: Amerikiniu šaltekšniu Chittem Bark; Kaszkarabokor kéreg; Kůra řešetláku Purshova; Rhamni purshianae cortex; Rhamni Purshiani Cortex; Sacred Bark; Sagradabark; Sagradankuori.
Cyrillic synonym: Жостер Пурша; Крушина Пурша.

💊 Chemical information

CAS — 8047-27-6; 8015-89-2 (cascara sagrada extract).
ATC — A06AB07.
ATC Vet — QA06AB07.

Pharmacopoeias.

In Eur. and US.

Ph. Eur. 6.2

(Cascara). The dried, whole or fragmented bark of Rhamnus purshianus (=Frangula purshiana). It contains not less than 8.0% of hydroxyanthracene glycosides of which not less than 60% consists of cascarosides, both expressed as cascaroside A (C 27 H 32 O 14 = 580.5). and calculated with reference to the dried drug. Protect from light.

USP 31

(Cascara Sagrada). The dried bark of Rhamnus purshianus (Rhamnaceae). It contains not less than 7% of total hydroxyanthracene derivatives calculated on the dried basis, of which not less than 60% consists of cascarosides, both calculated as cascaroside A. It has a distinct odour.

💊 Profile

Cascara is an anthraquinone stimulant laxative with general properties similar to those of senna. It has been used in the treatment of constipation in oral doses equivalent to about 20 mg of total hydroxyanthracene derivatives daily.

Breast feeding.

No adverse effects have been seen in breastfed infants whose mothers were receiving cascara, and the American Academy of Pediatrics considers1 that it is therefore usually compatible with breast feeding.
1. American Academy of Pediatrics. The transfer of drugs and other chemicals into human milk. Pediatrics 2001; 108: 776–89. Correction. ibid.; 1029. Also available at: http://aappolicy.aappublications.org/cgi/content/full/ pediatrics%3b108/3/776 (accessed 08/11/06)

💊 Preparations

BP 2008: Cascara Dry Extract; Cascara Tablets; USP 31: Aromatic Cascara Fluidextract; Cascara Sagrada Extract; Cascara Sagrada Fluidextract; Cascara Tablets.

Proprietary Preparations

Arg.: Natulax; Braz.: Laxsotrin; Fr.: Peristaltine; Ger.: Legapas; Port.: Laxolen†. Multi-ingredient: Arg.: Bilidren; Calculina†; Cascara Sagrada Bouzen†; Cascara Sagrada Oligoplex; Cascara Sagrada Puler†; Veracolate; Yuyo; Austral.: Colax; Peritone; Austria: Cascara-Salax; Dragees Neunzehn†; Silberne; Belg.: Grains de Vals; Vethoine; Braz.: Bilifel†; Boldopeptan†; Chofranina; Composto Emagrecedor†; Emagrevit†; Eparema; Jurubileno†; Pilulas De Witt’s†; Prisoventril†; Solvobil; Ventre Livre†; Canad.: Bicholate; Cholasyn II; Cholasyn†; Control; Doulax; Extra Strong Formula 12†; Herbal Laxative; Herbal Laxative plus Yogurt; Herbal Laxative†; Herbalax†; Herbolax; Herborex; Laxaco; Laxative†; Mucinum†; Thunas Laxative†; Chile: Bulgarolax; Fr.: Dragees Fuca; Dragees Vegetales Rex; Grains de Vals; Imegul†; Mucinum a l’Extrait de Cascara; Hong Kong: Mucinum Cascara†; Ital.: Amaro Medicinale; Coladren; Combilax; Confetti Lassativi CM; Critichol; Digelax†; Dis-Cinil Complex; Draverex; Eparema; Eparema-Levul; Eupatol; Fave di Fuca; Grani di Vals; Hepatos; Hepatos B12; Lassatina†; Magisbile†; Mepalax; Schias-Amaro Medicinale†; Solvobil; Stimolfit; Vadolax†; Norw.: Cosylan; Port.: Caroid†; Mucinum; S.Afr.: Moultons Herbal Extract; Veracolate†; Spain: Crislaxo; Lipograsil; Menabil Complex†; Nico Hepatocyn; Pildoras Zeninas; Swed.: Emulax; Switz.: Padma-Lax; Padmed Laxan; Thai.: Flatulence; Hemolax; Veracolate; UK: Dual-Lax Extra Strong; Dual-Lax Normal Strength; Jacksons Herbal Laxative; Laxative Tablets; Modern Herbals Laxative; Modern Herbals Pile; Natural Herb Tablets; Out-of-Sorts; Pileabs; Piletabs; Rhuaka; Senokot Dual Relief; Skin Eruptions Mixture; USA: Concentrated Milk of Magnesia-Cascara; Venez.: Gameral.
Published December 12, 2018.