Tosylchloramide Sodium

(BAN, rINN)
Tosylchloramide Sodium Chemical formula
Synonyms: Chloramidum; Chloramina; Chloramine; Chloramine T; Chloraminum; Cloramina; Klóramin; Mianin; Natrium Sulfaminochloratum; Tosilchloramido natrio druska; Tosilcloramida sódica; Tosylchloramid sodná sůl trihydrát; Tosylchloramide sodique; Tosylchloramidum natricum; Tosylchloramidum Natricum Trihydricum; Tosylkloramidnatrium; Tosyylikloramidinatrium. Sodium Nchlorotoluenep-sulphonimidate trihydrate.
Cyrillic synonym: Тозилхлорамид Натрий.

💊 Chemical information

Chemical formula: C7H7ClNNaO2S,3H2O = 281.7.
CAS — 144-86-5 (tosylchloramide); 127-65-1 (tosylchloramide sodium).
ATC — D08AX04.
ATC Vet — QD08AX04.

Pharmacopoeias.

In Eur. and Viet.

Ph. Eur. 6.2

(Tosylchloramide Sodium). A white or slightly yellow, crystalline powder. Freely soluble in water; soluble in alcohol. A 5% solution in water has a pH of 8.0 to 10.0. Store in airtight containers. Protect from light.

💊 Adverse Effects and Treatment

Vomiting, cyanosis, circulatory collapse, frothing at the mouth, and respiratory failure can occur within a few minutes of tosylchloramide sodium ingestion. Fatalities have occurred. Tosylchloramide sodium in tap water has caused methaemo globinaemia and haemolysis in patients undergoing dialysis. Bronchospasm has occurred after inhalation. Treatment of adverse effects is similar to that for Sodium Hypochlorite.

Effects on the lungs.

A study in Finland in dental staff who had reported occupational respiratory hypersensitivity between 1990 and 1998 found that 1 of 28 cases of rhinitis and 3 of 28 cases of asthma could be attributed to tosylchloramide sodium.1For further reference to respiratory effects associated with tosylchloramide sodium gas, see under Sodium Hypochlorite: Toxicity from mixing cleaning agents.
1. Piirilä P, et al. Occupational respiratory hypersensitivity in dental personnel. Int Arch Occup Environ Health 2002; 75: 209–16.

💊 Uses and Administration

Tosylchloramide sodium is an organic chlorine-releasing compound. It has general properties similar to those of chlorine but is more stable. It contains about 25% w/w of ‘available chlorine’. It is stable at an alkaline pH although it is much more active in acid media. It is more slowly active than hypochlorite solutions. Tosylchloramide sodium is used for the treatment of minor wound infections and as a skin and hard surface disinfectant. It is also used for the treatment of drinking water. It was formerly used as a spermicide. Tosylchloramide sodium B (chlorogenium; sodium N-chlorobenzenesulphonimidate sesquihydrate) has been used similarly to tosylchloramide sodium.

💊 Preparations

Proprietary Preparations

Belg.: Chloraseptine; Chlorazol; Chloronguent; Clonazone; Fr.: Hydroclonazone; Ger.: Chloramin T; Clorina; Trichlorol; Hung.: Neomagnol; Ital.: Amuclor Med; Citromed Chlor; Dermedal; Euclorina; Minachlor; Ottoclor†; Steridrolo; Spain: Clorina.
Published February 07, 2019.