Thymol

(BAN, rINN)
Thymol Chemical formula

💊 Chemical information

Acido Timico; Isopropylmetacresol; Thymolum; Timol; Timolis; Tym ol; Ty moli. 2Is opropy l5met hylp he no l.
Chemical formula: C10H14O = 150.2.
CAS — 89-83-8.
ATC Vet — QP53AX22.

Pharmacopoeias.

In Eur. and Jpn. Also in USNF.

Ph. Eur. 6.2

(Thymol). Colourless crystals. The melting range is 48° to 52°. Very slightly soluble in water; very soluble in alcohol; freely soluble in volatile and in fixed oils; sparingly soluble in glycerol; dissolves in dilute solutions of alkali hydroxides. Protect from light.

USNF 26

(Thymol). Colourless, often large, crystals or a white crystalline powder with an aromatic thyme-like odour. The melting range is 48° to 51°; when melted it remains liquid at a considerably lower temperature. Soluble 1 in 1000 of water, 1 in 1 of alcohol and of chloroform, 1 in 1.5 of ether, and 1 in 2 of olive oil; soluble in glacial acetic acid and in fixed and volatile oils. Store in airtight containers. Protect from light.

Incompatibility.

The antimicrobial activity of thymol is reduced by combination with protein.

💊 Adverse Effects, Treatment, and Precautions

As for Phenol. When ingested, thymol is less toxic than phenol. It is irritant to the gastric mucosa. Fats and alcohol increase absorption and aggravate the toxic symptoms.

Hypersensitivity.

Contact allergy to a heparinoid cream was due to an allergen formed by the reaction between thymol and the degradation products of a triazine derivative, both present as preservatives.1
1. Smeenk G, et al. Contact allergy to a reaction product in Hirudoid cream: an example of compound allergy. Br J Dermatol 1987; 116: 223–31.

💊 Uses and Administration

Thymol is a phenolic antiseptic with antibacterial and antifungal activity. It is more powerful than phenol but its use is limited by its low solubility in water, irritancy, and susceptibility to protein. Thymol is used chiefly as a deodorant in mouthwashes and gargles such as Compound Thymol Glycerin (BP 1988), an aqueous mixture of thymol 0.05% and glycerol 10% with colouring and flavouring, which may be used diluted with about 3 times its volume of warm water before use. Thymol has been used topically in the treatment of skin disorders and is also inhaled, with other volatile substances, for colds, coughs, and associated respiratory disorders. Thymol 0.01% is added as an antoxidant to halothane, trichloroethylene, and tetrachloroethylene. Thymol iodide is used in preparations for dental hygiene.

💊 Preparations

Proprietary Preparations

Ger.: Medophyll†; S.Afr.: Cool Mint Listerine; Freshburst Listerine. Multi-ingredient: Arg.: Fungicida†; Listerine Clasico; Listerine Cool Mint; Listerine Fresh Burst; Manzan; Novobroncol†; Periobacter Prof Avio; Vagicural; Austral.: SM-33; Vicks Vaporub; Austria: Alpicort; Criniton; DDD; Gingivan; Kinder Luuf; Luuf Balsam; Pe-Ce; Spasmo Claim; Thrombocid; Wick Vaporub; Belg.: Borostyrol; Dentophar; Perubore; Vicks Vaporub; Braz.: Anestesiol†; Angino-Rub; Cloraseptic; Cutisanol; Fluomint; Frixodon†; Gargotan†; Gyrol†; Lenidor†; Passaja†; Relampago†; Tabletes Valda†; Valda†; Vick Vaporub; Canad.: Antiseptic Mouthwash; Boil Ease†; Buckley’s White Rub†; Carboseptol†; Lipsorex Plus; Lipsorex†; Listerine; Listerine Antiseptic Tartar Control; Mouthwash Antiseptic & Gargle†; Nasal Jelly†; Thermo-Gel; Valda; Vaporisateur Medicamente; Vaporizing Ointment; Chile: Balsamo Leon†; Galutec†; Hansaplast Descongestionante; Listerine; Listermint Con Fluor; Oralfresh Citrus; Oralfresh Clasico; Polisep†; Cz.: Parodontal F5†; Pinosol; Septolete; Fin.: Vicks Vaporub; Fr.: Borostyrol; Listerine; Listerine protection dents et gencives; Moustidose; Nisacalm; Pastilles Medicinales Vicks; Perubore; Valda; Vicks Vaporub; Ger.: Alferm†; Criniton†; Em-medical†; Nasentropfen-ratiopharm†; Oestrugol N†; Pulmotin; Retterspitz Ausserlich; Retterspitz Quick; Salviathymol N; Thrombocid; Gr.: Oulogram; Hong Kong: Burn Cream†; Cool Mint Listerine; Gly Thymol; Kamistad; Listerine; Listerine Tartar Control; Listerine Teeth and Gum Defence; Salomethyl; Valda†; India: Anaebell†; Indon.: Dactylen; Listerine; Listerine Coolmint; Skintex; Vital Ear Oil; Irl.: Karvol; Valda†; Israel: Gargol; Garonsept; Karvol; Pronestin; Rectozorin; Ital.: Eucalipto Composto†; Eugenol-Guaiacolo Composto; Listerine Fresh Citrus; Listerine Tartar Control; Pinselina Knapp; Rinostil; Malaysia: Listerine†; Salonpas; Mex.: Dermacid; Listerine; Neth.: Vicks Vaporub; NZ: Listerine; Listerine Tartar Control; Thymol Mouthwash Red†; Vicks Vaporub; Philipp.: Calmoseptine; Listerine Coolmint; Listerine Fresh Citrus; Listerine Freshburst; Listerine Original; Listerine Tartar Control; Listerine Teeth & Gum Defense; Mentopas; Pol.: Afronis; Bronchosol; Derhotill; Icy Rub; Pinosol; Pulmonil; RubArom; Septolete; Sonol; Wick Vaporub; Port.: Edoltar†; Freimax†; Listerine†; Thrombocid; Valda†; Rus.: Bioprost (Биопрост); Doktor Mom (Доктор Мом); Efcamon (Эфкамон); Pinosol (Пиносол); Septogal (Септогал); Septolete (Септолете); Suprima-Plus (Суприма-Плюс); S.Afr.: Karvol; Listerine Antiseptic; Prep; Tartar Control Listerine Antiseptic; Vicks Vaporub; Singapore: Kamistad; Karvol; Listerine; Listerine Cool Mint; Listerine Fresh Burst; Listerine Tartar Control; Spain: Balsamo Kneipp†; Co Bucal; Mentobox; Pastillas Antisep Garg M; Piorlis; Vicks Vaporub; Swed.: Vicks Vaporub†; Switz.: Asphaline†; Borostyrol N†; Butaparin; Cresophene†; Ederphyt; Furodermal; GU Eau†; Huile analgesique "Temple of Heaven" contre les maux de tete†; Penta; Perubare†; Rapura; Sedasept†; Sedotussin†; Thrombocid; Vicks Vaporub N; Thai.: Burnol Plus; Flavinol; Kamistad; Stopain; Turk.: Kataljin; Mentimol; Mentolin; Otaci Meyanbali; Otaci Oka Mentol; Otaci Salvia; Vicks Vaporub; UK: Antiseptic Mouthwash; DDD; Dragon Balm; Karvol; Listerine Antiseptic Mouthwash; No-Sor Vapour Rub; Potter’s Catarrh Pastilles; USA: BFI; Boil Ease; Listerine; Massengill; Vicks Menthol Cough Drops; Zonite; Venez.: Amicets; Lafarcaina.
Published February 07, 2019.