Propamidine Isetionate

(BANM, rINNM)
Propamidine Isetionate Chemical formula
Synonyms: Isetionato de propamidina; M&B-782; Propamidine Isethionate; Propamidine, Isétionate de; Propamidini Isetionas. 4,4′-Trimethylenedioxydibenzamidine bis(2-hydroxyethanesulphonate).
Cyrillic synonym: Пропамидина Изетионат.

💊 Chemical information

Chemical formula: C17H20N4O2,2C2H6O4S = 564.6.
CAS — 104-32-5 (propamidine); 140-63-6 (propamidine isetionate).
ATC — D08AC03; S01AX15.
ATC Vet — QD08AC03; QS01AX15.

💊 Profile

Propamidine isetionate is an aromatic diamidine antiseptic that is active against Gram-positive bacteria, but less active against Gram-negative bacteria and spore-forming organisms. It also has antifungal properties and is active against Acanthamoeba. Ophthalmic solutions containing 0.1% of propamidine isetionate are used for the treatment of conjunctivitis and blepharitis.

Acanthamoeba keratitis.

The optimal regimen for the treatment of Acanthamoeba keratitis has yet to be determined. Propamidine isetionate applied topically was the first drug used with some success.1,2 It was used with an aminoglycoside such as neomycin or a neomycin-polymyxin-gramicidin preparation and a cure was achieved in about 50% of cases. Due to surface toxicity and poor in-vitro sensitivity of neomycin, propamidine was later used with chlorhexidine or polihexanide. However, poor cysticidal activity, chronic conjunctival infection, and resistance of some strains of Acanthamoeba to propamidine has prompted the suggestion that it should be replaced by another diamidine such as hexamidine.3
1. Murdoch D, et al. Acanthamoeba keratitis in New Zealand, including two cases with in vivo resistance to polyhexamethylene biguanide. Aust N Z J Ophthalmol 1998; 26: 231–6
2. Seal DV. Acanthamoeba keratitis update—incidence, molecular epidemiology and new drugs for treatment. Eye 2003; 17: 893–905
3. Perrine D, et al. Amoebicidal efficiencies of various diamidines against two strains of Acanthamoeba polyphaga. Antimicrob Agents Chemother 1995; 39: 339–42.

💊 Preparations

Proprietary Preparations

Austral.: Brolene; Irl.: Brolene; NZ: Brolene; S.Afr.: Brolene; UK: Brolene; Golden Eye Drops.
Published January 31, 2019.