💊 Chemical information
CAS — 8013-52-3 (ethyl alcohol-methyl alcohol mixture; industrial methylated spirit).
Description.Three classes of methylated spirits are listed under the Methylated Spirits Regulations, 1987 (SI 1987: No. 2009): industrial methylated spirits, mineralised methylated spirits, and denatured ethanol (denatured alcohol). Industrial Methylated Spirits is defined as 95 parts by volume of spirits mixed with wood naphtha 5 parts by volume. Mineralised methylated spirits is spirits mixed with wood naphtha 9.5 parts by volume and crude pyridine 0.5 parts by volume, and to every 2000 litres of this mixture is added 7.5 litres of mineral naphtha (petroleum oil) and 3 g of synthetic organic dyestuff (methyl violet). This is the only variety that may be sold in Great Britain for general use. Denatured ethanol is 999 parts by volume of spirits (of a strength not less than 85%) mixed with 1 part by volume of tertiary butyl alcohol, and to this mixture is added Bitrex (denatonium benzoate) 10 mg/litre. As Industrial Methylated Spirit may contain small amounts of acetone it should not be used for the preparation of iodine solutions, since an irritating compound is formed by reaction between iodine and acetone; for such preparations Industrial Methylated Spirit (Ketone-free) should be used.
Pharmacopoeias.Br. includes Industrial Methylated Spirit and Industrial Methylated Spirit (Ketone-free).
BP 2008 (Industrial Methylated Spirit). A mixture of 19 volumes of ethyl alcohol of an appropriate strength with 1 volume of approved wood naphtha. Two strengths are available containing 99% and 95% v/v alcohol (also known as 74 OP and 66 OP respectively). It is a colourless, clear, mobile, volatile liquid with an odour which is spirituous and of wood naphtha. B.p. is about 78°. The
BP 2008 gives Industrial Methylated Spirits and IMS as approved synonyms.
BP 2008 (Industrial Methylated Spirit (Ketone-free)). A mixture of the same strength as Industrial Methylated Spirit, but it is substantially free from ketones, containing not more than the equivalent of 500 ppm of acetone.
💊 Adverse Effects
As for Alcohol, and Methyl Alcohol. Adverse effects are due chiefly to consumption of methylated spirits rather than its topical use as a disinfectant.
💊 Uses and Administration
Industrial methylated spirit, in a concentration of about 70%, is the usual form in which alcohol is used for disinfection. It is applied externally for its astringent action, but mucous membranes and excoriated skin surfaces must be protected. It may be used for skin preparation before injection. Methylated spirits may be used in the form of Surgical Spirit (BP 2008), a mixture of methyl salicylate (0.5% v/v), diethyl phthalate (2% v/v), and castor oil (2.5% v/v) in industrial methylated spirit.
BP 2008: Surgical Spirit.
Proprietary PreparationsItal.: Esosan Gel.
Published January 19, 2019.