Zipeprol Hydrochloride

(rINNM)
Zipeprol Hydrochloride Chemical formula
Synonyms: CERM-3024; Hidrocloruro de zipeprol; Zipéprol, Chlorhydrate de; Zipeproli Hydrochloridum. oxyphenethyl)-1-piperazineethanol dihydrochloride.
Cyrillic synonym: Зипепрола Гидрохлорид.

💊 Chemical information

Chemical formula: C23H32N2O3,2HCl = 457.4.
CAS — 34758-83-3 (zipeprol); 34758-84-4 (zipeprol hydrochloride).
ATC — R05DB15.
ATC Vet — QR05DB15.

💊 Profile

Zipeprol is a centrally acting cough suppressant that is stated to have a peripheral action on bronchial spasm. It has been given as the hydrochloride, typically in an oral dose of 150 to 300 mg daily in divided doses. There have been reports of abuse and overdosage producing neurological symptoms.

Abuse and overdosage.

Severe neurological symptoms have been reported in young adults after habitual abuse of zipeprol for euphoria. Patients have presented with generalised seizures, followed by coma.1 One patient who ingested 750 mg of zipeprol [over twice the maximum daily dose] had several opisthotonic crises and developed cerebral oedema.2 Symptoms of overdosage in children have included restlessness, somnolence, ataxia, choreic movements, forced deviation of the head and eyes, generalised seizures, respiratory depression, and coma.1,3 Fatalities have been reported. Dependence and withdrawal symptoms similar to those produced by opioids have been reported.4 WHO has assessed zipeprol to have a moderate potential for dependence and liability for abuse.5 Although zipeprol is a weak opioid agonist at high doses its toxicity and hallucinogenic and other psychotropic effects constitute a significant element in its abuse, and the public health and social problems associated with such abuse were considered substantial.
1. Moroni C, et al. Overdosage of zipeprol, a non-opioid antitussive agent. Lancet 1984; i: 45
2. Perraro F, Beorchia A. Convulsions and cerebral oedema associated with zipeprol abuse. Lancet 1984; i: 45–6
3. Merigot P, et al. Les convulsions avec trois antitussifs dérivés substitués dé la pipérazine (zipéprol, éprazinone, éprozinol). Ann Pediatr (Paris) 1985; 32: 504–11
4. Mallaret MP, et al. Zipeprol: primary dependence in an unaddicted patient. Ann Pharmacother 1995; 29: 540
5. WHO. WHO expert committee on drug dependence: twentyninth report. WHO Tech Rep Ser 856 1995. Also available at: http://whqlibdoc.who.int/trs/WHO_TRS_856.pdf (accessed 11/05/07)

💊 Preparations

Proprietary Preparations

Chile: Frenotos; Gr.: Dovavixin†; Duo-Extolen†; Jactuss†; Mex.: Respilene†; Tusigen; Venez.: Coloplex†.
Published October 07, 2018.