Zinc Oxide

(USAN)
Synonyms: Blanc de Zinc; Blanco de zinc; Cinko oksidas; Çinko Oksit; Cinkoxid; Cynku tlenek; Flores de zinc; Flowers of Zinc; Oxid zinečnatý; Sinkkioksidi; Zinc, óxido de; Zinc, oxyde de; Zinci oxidum; Zinci Oxydum; Zincum Oxydatum; Zinkoxid.
Cyrillic synonym: Окись Цинка; Цинк Оксид.

💊 Chemical information

ZnO = 81.38.
CAS — 1314-13-2.

Pharmacopoeias.

In Chin., Eur., Int., Jpn, US, and Viet. US also includes a neutral zinc oxide.

Ph. Eur. 6.2

(Zinc Oxide). A white or faintly yellowish-white, soft, amorphous powder, free from gritty particles. Practically insoluble in water and in alcohol; it dissolves in dilute mineral acids.

USP 31 (Zinc Oxide). A white or yellowish-white, odourless, amorphous, very fine powder, free from grittiness. It gradually absorbs carbon dioxide from air. Insoluble in water and in alcohol; soluble in dilute acids.

USP 31 (Zinc Oxide, Neutral). It is for use in sunscreen preparations only.

Incompatibility.

Black discoloration has been reported when zinc oxide and glycerol are in contact in the presence of light.

💊 Profile

Zinc oxide is mildly astringent and is used topically as a soothing and protective application in eczema and slight excoriations, in wounds, and for haemorrhoids. It is also used with coal tar or ichthammol in the treatment of eczema. Zinc oxide reflects ultraviolet radiation and is used as a physical sunscreen. In the USA the name calamine is used for zinc oxide with a small proportion of ferric oxide. Zinc oxide is used as the basis for the production of a number of dental cements. Mixed with phosphoric acid it forms a hard material composed largely of zinc phosphate; mixed with clove oil or eugenol, it is used as temporary dental filling. For further details of zinc and its salts.

Complications of dental use.

Solitary aspergillosis of the maxillary sinus in 29 of 30 patients was associated with zinc oxide from overfilled teeth.1 Treatment consisted of removal of the fungal ball containing the zinc oxide; no antifungal treatment was necessary. Zinc oxide has been shown to accelerate the growth of Aspergillus fumigatus. Further cases have been reported, and adjunctive systemic antifungal treatment has been used.2
1. Beck-Mannagetta J, et al. Solitary aspergillosis of maxillary sinus, a complication of dental treatment. Lancet 1983; ii: 1260
2. Martins WD, Ribeiro Rosa EA. Aspergillosis of the maxillary sinus: review and case report. Scand J Infect Dis 2004; 36: 758–61.

💊 Preparations

BP 2008: Aqueous Calamine Cream; Calamine and Coal Tar Ointment; Calamine Lotion; Coal Tar and Zinc Ointment; Coal Tar Paste; Compound Aluminium Paste; Compound Zinc Paste; Dithranol Paste; Hexachlorophene Dusting Powder; Zinc and Castor Oil Ointment; Zinc and Coal Tar Paste; Zinc and Ichthammol Cream; Zinc and Salicylic Acid Paste; Zinc Cream; Zinc Ointment; USP 31: Calamine Topical Suspension; Coal Tar Ointment; Compound Resorcinol Ointment; Zinc Oxide and Salicylic Acid Paste; Zinc Oxide Ointment; Zinc Oxide Paste.

Proprietary Preparations

Arg.: Balmex†; Caladaryl Panal†; Dermic; Pasta Dermic†; Sinamida-D†; Zincoxid; Austral.: Curash Anti-Rash; Prickly Heat Powder; Rectogesic; Ungvita†; Zinc Cream White; Zincaband†; Zink’N’Swim†; Canad.: Aveeno Diaper Rash; Babys Own Ointment†; Egozinc; Infazinc; Johnson’s Diaper Rash; Johnson’s Medicated†; Triple Care Cream†; Woodward’s Diaper Rash; Zincoderm; Zincofax; Chile: Nenegloss Z; Denm.: Zipzoc; Fin.: Zipzoc; Fr.: Babygella; Filorga Soin Ecran Solaire; Mylange Creme†; Oxyplastine; Senophile†; Veinopress A3 and A4; Ger.: Cutaninfant†; Desitin†; FissanZinkschuttelmixtur†; Labiosan; Pantederm N; Pinal S†; Retterspitz Heilsalbe ST; Robuvalen†; St. Jakobs-Balsam; Zinkpaste; Zinksalbe Dialon†; Zinksalbe Lichtenstein; Hong Kong: Desitin Daily Care†; India: Belle Cream†; Irl.: Viscopaste; Zipzoc; Israel: Dyprotex; Lotio Zinc; Lotio Zinci; Zinc Lotion; Ital.: Ceroxmed Tex; Delicate Skin Pasta; Gelocast; Gelostretch; Milsana; Oz; Scherilan Crema; Sicura3 Fisionorm; Tayderm; Tendigrip; Triderm Crema; Triderm Zeta; Varicex; Viscopaste PB7; Zinco All’ Acqua†; Zincoderm; Mex.: Pasta de Lassar; Rosatil BB†; Saniderm; Neth.: Daroderm Zinkzalf; Zinkolie; Zinkzalf; Zipzoc; Philipp.: Curash; Desitin; Spectraban 19; Port.: Lassadermil; Oleo Dermosina Simples†; Zincoderma; Zipzoc; Rus.: Desitin (Деситин); S.Afr.: Clocktower; Johnson’s Baby Nappy Rash Ointment; Vernleigh Baby Cream; Viscopaste PB7; Singapore: Desitin†; Spain: Anticongestiva; Swed.: Zipzoc Salvstrumpa; Switz.: Oxyplastine; Pelsano; Pommade Congo†; ZinCream; Thai.: Nappy-Hippo; Spectraban; UAE: Proskin; UK: Steripaste; Viscopaste PB7; Zincaband; Zipzoc; USA: Borofax; Delazinc; Diaparene Diaper Rash; Dr Smiths; Nupercainal†; Triple Paste; Venez.: Lanol-Zinc; Oxyphar.
Published January 25, 2019.