Ustekinumab

(USAN, pINN)
Synonyms: CNTO-1275; Ustékinumab; Ustekinumabum. Immunoglobulin G1, anti-(human interleukin-12 subunit beta (IL-12B, CLMF p40, NKSF2))(human monoclonal CNTO 1275 with human monoclonal CNTO 1275
Cyrillic synonym: Устекинумаб.

Chemical information

CAS — 815610-63-0.

Profile

Ustekinumab is a human monoclonal antibody that binds to interleukins 12 and 23. It is under investigation in the treatment of psoriasis.
1. Krueger GG, et al. A human interleukin-12/23 monoclonal antibody for the treatment of psoriasis. N Engl J Med 2007; 356: 580–92
2. Leonardi CL, et al. Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebocontrolled trial (PHOENIX 1). Lancet 2008; 371: 1665–74. Correction. ibid.; 1838
3. Papp KA, et al. Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebocontrolled trial (PHOENIX 2). Lancet 2008; 371: 1675–84.
Published January 24, 2019.