Synonyms: NSC-71047; 4,5′,8-Trimethylpsoralen; Trioksisaleeni; Trioxisalen; Trioxisaleno; Trioxsalen 2,5,9-Trimethyl-7H-furo[3,2g]benzopyran-7-one.
Cyrillic synonym: Триоксизален.
💊 Chemical information
Chemical formula: C14H12O3 = 228.2.
CAS — 3902-71-4.
ATC — D05AD01; D05BA01.
ATC Vet — QD05AD01; QD05BA01.
USP 31(Trioxsalen). A white to off-white or greyish, odourless, crystalline solid. Practically insoluble in water; soluble 1 in 1150 of alcohol, 1 in 84 of chloroform, 1 in 43 of dichloromethane, and 1 in 100 of methyl isobutyl ketone. Protect from light.
Trioxysalen, a psoralen, is a photosensitiser used similarly to methoxsalen in photochemotherapy or PUVA therapy. Trioxysalen is used in idiopathic vitiligo to enhance pigmentation or increase the tolerance to sunlight in selected patients. In vitiligo an oral dose of 10 mg daily is given 2 to 4 hours before exposure to sunlight or ultraviolet radiation; prolonged therapy may be necessary. To increase tolerance to sunlight a dose of 10 mg daily is given 2 hours before exposure; treatment should not be continued for longer than 14 days. Trioxysalen may also be used topically in the PUVA treatment of psoriasis.
1. Snellman E, Rantanen T. Concentration-dependent phototoxicity in trimethylpsoralen bath psoralen ultraviolet A. Br J Dermatol 2001; 144: 490–4.
USP 31: Trioxsalen Tablets.
Proprietary PreparationsArg.: Trisoralen†; Fin.: Tripsor ; Gr.: Trisolaren; Hong Kong: Puvadin†; India: Neosoralen†; Malaysia: Puvadin†.
Published January 24, 2019.