Trioxysalen

(rINN)
Trioxysalen Chemical formula
Synonyms: NSC-71047; 4,5′,8-Trimethylpsoralen; Trioksisaleeni; Trioxisalen; Trioxisaleno; Trioxsalen 2,5,9-Trimethyl-7H-furo[3,2g][1]benzopyran-7-one.
Cyrillic synonym: Триоксизален.

💊 Chemical information

Chemical formula: C14H12O3 = 228.2.
CAS — 3902-71-4.
ATC — D05AD01; D05BA01.
ATC Vet — QD05AD01; QD05BA01.

Pharmacopoeias.

In US.

USP 31

(Trioxsalen). A white to off-white or greyish, odourless, crystalline solid. Practically insoluble in water; soluble 1 in 1150 of alcohol, 1 in 84 of chloroform, 1 in 43 of dichloromethane, and 1 in 100 of methyl isobutyl ketone. Protect from light.

💊 Profile

Trioxysalen, a psoralen, is a photosensitiser used similarly to methoxsalen in photochemotherapy or PUVA therapy. Trioxysalen is used in idiopathic vitiligo to enhance pigmentation or increase the tolerance to sunlight in selected patients. In vitiligo an oral dose of 10 mg daily is given 2 to 4 hours before exposure to sunlight or ultraviolet radiation; prolonged therapy may be necessary. To increase tolerance to sunlight a dose of 10 mg daily is given 2 hours before exposure; treatment should not be continued for longer than 14 days. Trioxysalen may also be used topically in the PUVA treatment of psoriasis.
1. Snellman E, Rantanen T. Concentration-dependent phototoxicity in trimethylpsoralen bath psoralen ultraviolet A. Br J Dermatol 2001; 144: 490–4.

💊 Preparations

USP 31: Trioxsalen Tablets.

Proprietary Preparations

Arg.: Trisoralen†; Fin.: Tripsor ; Gr.: Trisolaren; Hong Kong: Puvadin†; India: Neosoralen†; Malaysia: Puvadin†.
Published January 24, 2019.