Trichloroacetic Acid

(BAN, USAN, rINN)
Trichloroacetic Acid Chemical formula
Synonyms: Acide Trichloracétique; Acidum trichloraceticum; Acidum Trichloroaceticum; Kwas trichlorooctowy; Kyselina trichloroctová; Trichloracetic Acid; Trichloracto ru _ gštis; Trichloressigsäure; Tricloroacético, ácido; Trikloorietikkahappo; Triklorättiksyra; Triklórecetsav.
Cyrillic synonym: Трихлоруксусная Кислота.

💊 Chemical information

Chemical formula: C2HCl3O2 = 163.4.
CAS — 76-03-9.

Pharmacopoeias.

In Eur..

Ph. Eur. 6.2

(Trichloroacetic Acid). A very deliquescent white or almost white crystalline mass or colourless crystals. Very soluble in water, in alcohol, and in dichloromethane. Store in airtight containers.

💊 Adverse Effects and Treatment

💊 Uses and Administration

Trichloroacetic acid is caustic and astringent. When used as an escharotic for warts it is applied as a strong solution; a range of concentrations have been used including 50% and 80%. The surrounding areas of skin should be protected. Trichloroacetic acid has also been used for the removal of tattoos and in cosmetic surgery for chemical peeling of the skin.

Tattoo removal.

References to the use of trichloroacetic acid in the removal of tattoos.
1. Hall-Smith P, Bennett J. Tattoos: a lasting regret. BMJ 1991; 303: 397.

Warts.

References to the use of trichloroacetic acid in the treatment of genital warts.
1. Godley MJ, et al. Cryotherapy compared with trichloroacetic acid in treating genital warts. Genitourin Med 1987; 63: 390–2
2. Davis AJ, Emans SJ. Human papilloma virus infection in the pediatric and adolescent patient. J Pediatr 1989; 115: 1–9
3. Boothby RA, et al. Single application treatment of human papillomavirus infection of the cervix and vagina with trichloroacetic acid: a randomized trial. Obstet Gynecol 1990; 76: 278–80
4. Abdullah AN, et al. Treatment of external genital warts comparing cryotherapy (liquid nitrogen) and trichloroacetic acid. Sex Transm Dis 1993; 20: 344–5.

💊 Preparations

Proprietary Preparations

Hong Kong: AccuPeel†; Ital.: CL tre; Verrupor; Singapore: AccuPeel†; USA: Tri-Chlor. Multi-ingredient: Spain: Callicida Brum†; Turk.: IL-33.
Published January 24, 2019.