Tacalcitol

(BAN, rINN)
Tacalcitol Chemical formula
Synonyms: 1α,24-Dihydroxycholecalciferol; 1α,24-Dihydroxyvitamin D 3 ; Tacalcitolum; Takalsitol. (+)-(5Z,7E,24R)-9,10-Secocholesta5,7,10(19)-triene-1
Cyrillic synonym: Такальцитол.

💊 Chemical information

Chemical formula: C27H44O3,H2O = 434.7.
CAS — 57333-96-7 (anhydrous tacalcitol); 93129-94-3 ATC — D05AX04.
ATC Vet — QD05AX04.

💊 Adverse Effects and Precautions

As for Calcipotriol. Paraesthesia may also occur. Tacalcitol may be applied to the face, but care should be taken to avoid the eyes. Tacalcitol may be degraded by UV radiation (see Uses and Administration, below).

💊 Uses and Administration

Tacalcitol is a vitamin D3 derivative, with actions and uses similar to those of calcipotriol. Tacalcitol is applied topically in the management of plaque psoriasis. It is used as the monohydrate, but the concentration is expressed in terms of anhydrous tacalcitol; 4.17 micrograms of tacalcitol monohydrate is equivalent to about 4 micrograms of tacalcitol. It is applied as an ointment containing the equivalent of tacalcitol 4 micrograms/g (0.0004%). Applications are made once daily, preferably at bedtime, and no more than 10 g of ointment should be applied each day. Duration of treatment depends on the severity of the lesions; continuous and intermittent treatments for up to 12 months have been used. Tacalcitol may be degraded by UV radiation and therefore if combined with UV therapy, the radiation should be given in the morning and tacalcitol applied at bedtime.
1. Peters DC, Balfour JA. Tacalcitol. Drugs 1997; 54: 265–71
2. Gollnick H, Menke T. Current experience with tacalcitol ointment in the treatment of psoriasis. Curr Med Res Opin 1998; 14: 213–18
3. Harrison PV. Topical tacalcitol treatment for psoriasis. Hosp Med 2000; 61: 402–5
4. Van de Kerkhof PCM, et al. Long-term efficacy and safety of tacalcitol ointment in patients with chronic plaque psoriasis. Br J Dermatol 2002; 146: 414–22
5. Lecha M, et al. Tacalcitol in the treatment of psoriasis vulgaris: the Spanish experience. J Eur Acad Dermatol Venereol 2005; 19: 414–17.

💊 Preparations

Proprietary Preparations

Arg.: Bonalfa†; Austria: Curatoderm; Belg.: Curatoderm; Chile: Bonalfa; Cz.: Curatoderm; Fr.: Apsor; Ger.: Curatoderm; Hung.: Curatoderm; Israel: Curatoderm; Ital.: Ticlapsor; Vellutan; Jpn: Bonalfa; Mex.: Bonalfa; Pol.: Curatoderm; Port.: Bonalfa; Spain: Bonalfa; Switz.: Curatoderm; UK: Curatoderm; Venez.: Bonalfa†.
Published January 19, 2019.