T4 Endonuclease V

(USAN, rINN)
Synonyms: Bacteriophage T4 Endodeoxyribonuclease V; T4N5. Coliphage T4 endodeoxyribonuclease V.
Cyrillic synonym: T4 Эндонуклеаза V.

Chemical information

CAS — 52227-85-7.

Profile

T4 endonuclease V is a DNA-repair enzyme that is reported to remove DNA damaged by UV radiation. It is under investigation to reduce the incidence of actinic keratosis and basal cell carcinoma in patients with xeroderma pigmentosum.
1. Wolf P, et al. Topical treatment with liposomes containing T4 endonuclease V protects human skin in vivo from ultravioletinduced upregulation of interleukin-10 and tumor necrosis factor-
α. J Invest Dermatol 2000; 114: 149–56.
2. Yarosh D, et al. Effect of topically applied T4 endonuclease V in liposomes on skin cancer in xeroderma pigmentosum: a randomised study. Lancet 2001; 357: 926–9.
Published January 18, 2019.