Squaric Acid Dibutylester

Squaric Acid Dibutylester Chemical formula
Synonyms: Éster dibutílico del ácido escuárico; Quadratic Acid Dibutylester; SADBE. The dibutyl ester of 3,4-dihydroxy-3-cyclobutene-1,2-dione; 3,4-Dibutoxy-3-cyclobutene-1,2-dione; .
Cyrillic synonym: Дибутиловый Эфир Сквариковой Кислоты.

Chemical information

Chemical formula: C12H18O4 = 226.3.


Squaric acid dibutylester has been tried similarly to diphencyprone as a contact sensitiser in the treatment of alopecia. It has also been tried in warts.
1. Tosti A, et al. Long-term results of topical immunotherapy in children with alopecia totalis or alopecia universalis. J Am Acad Dermatol 1996; 35: 199–201
2. Micali G, et al. Treatment of alopecia areata with squaric acid dibutylester. Int J Dermatol 1996; 35: 52–6
3. Lee AN, Mallory SB. Contact immunotherapy with squaric acid dibutylester for the treatment of recalcitrant warts. J Am Acad Dermatol 1999; 41: 595–9
4. Silverberg NB, et al. Squaric acid immunotherapy for warts in children. J Am Acad Dermatol 2000; 42: 803–8
5. Micali G, et al. Use of squaric acid dibutylester (SADBE) for cutaneous warts in children. Pediatr Dermatol 2000; 17: 315–18
6. Dall’Oglio F, et al. Adult and paediatric contact immunotherapy with squaric acid dibutylester (SADBE) for recurrent, multiple, resistant, mucocutaneous anogenital warts. Sex Transm Infect 2002; 78: 309–10
7. Dall’Oglio F, et al. Topical immunomodulator therapy with squaric acid dibutylester (SADBE) is effective treatment for severe alopecia areata (AA): results of an open-label, paired-comparison, clinical trial. J Dermatol Treat 2005; 16: 10–14
8. Ajith C, et al. Efficacy and safety of the topical sensitizer squaric acid dibutyl ester in alopecia areata and factors influencing the outcome. J Drugs Dermatol 2006; 5: 262–6.
Published January 16, 2019.