Skin Substitutes

(USAN)

💊 Chemical information

Sustitutos de la piel.

💊 Profile

Biological and semisynthetic materials have been developed for use as temporary dressings in burns, ulcers, and other injuries associated with skin loss. The rationale is to prevent fluid and heat loss, to reduce infection, to protect exposed structures, to reduce pain, and to prepare the site for grafting. Denatured porcine and bovine skin, consisting of the dermal and/or epidermal layers, have been used. More recently bioengineered human skin equivalents have been produced which more closely mimic human skin, as well as human, living dermal replacement products.
1. Supp DM, Boyce ST. Engineered skin substitutes: practices and potentials. Clin Dermatol 2005; 23: 403–12
2. Braye F, et al. Les substituts cutanés reconstruits en laboratoire: application au traitement des brûlés. Pathol Biol (Paris) 2005; 53: 613–17
3. Bar-Meir E, et al. Skin substitutes. Isr Med Assoc J 2006; 8: 188–91
4. Hrabchak C, et al. Biological skin substitutes for wound cover and closure. Expert Rev Med Devices 2006; 3: 373–85.

💊 Preparations

Proprietary Preparations

Arg.: Kytinon Lamina†; Kytinon Membrana†; Pel Cupron†; S.Afr.: Dermagraft; UK: Dermagraft; Myskin; TransCyte; USA: Apligraf; Dermagraft; Orcel; TransCyte. Multi-ingredient: Arg.: Kytinon ABC†; Kytinon ARHI†; Kytinon ATM†.
Published January 16, 2019.