Sinecatechins

(USAN)
Sinecatechins Chemical formula

💊 Chemical information

Kunecatechins. A mixture whose major constituents are (−)-epicatechin, (−)-epigallocatechin, the corresponding 3-gallate esters, and their corresponding epimers.
CAS — 811420-59-4 (sinecatechins); 490-46-0 (( )-epicatechin); 1257-08-5 (( )-epicatechin 3-O-gallate); 97074-1 (( )-epigallocatechin); 989-51-5 (( )-epigallocatechin 3-O-gallate).

💊 Profile

Sinecatechins is a mixture of complex polyphenols extracted from green tea leaves. Although its mechanism of action is unclear, sinecatechins is used in the treatment of external genital and perianal warts. A 15% ointment is applied 3 times daily until complete clearance of all warts, but for no longer than 16 weeks. Local adverse effects are common with the topical application of sinecatechins and include erythema, pruritus, burning, pain or discomfort, erosion or ulceration, oedema, induration, and vesicular rash. Less common effects include urethritis, pigmentation changes, and hyperaesthesia.
1. Gross G, et al. A randomized, double-blind, four-arm parallelgroup, placebo-controlled phase II/III study to investigate the clinical efficacy of two galenic formulations of Polyphenon E in the treatment of external genital warts. J Eur Acad Dermatol Ve ne re ol 2007; 21: 1404–12
2. Anonymous. Veregen: a botanical for treatment of genital warts. Med Lett Drugs Ther 2008; 50: 15–16
3. Gross G. Polyphenon E: Eine neue topische Therapie für Condylomata acuminata. Hautarzt 2008; 59: 31–5
4. Stockfleth E, et al. Topical Polyphenon E in the treatment of external genital and perianal warts: a randomized controlled trial. Br J Dermatol 2008; 158: 1329–38
5. Tatti S, et al. Sinecatechins, a defined green tea extract, in the treatment of external anogenital warts: a randomized controlled trial. Obstet Gynecol 2008; 111: 1371–9.

💊 Preparations

Proprietary Preparations

Ital.: Epinerve; USA: Veregen.
Published January 15, 2019.