Resorcinol Monoacetate

(rINN)
Synonyms: Acetato de resorcina; Resorcin Acetate; Resorcinol, monoacetato de. 3-Acetoxyphenol.
Cyrillic synonym: Резорцинола Моноацетат.

💊 Chemical information

Chemical formula: C8H8O3 = 152.1.
CAS — 102-29-4.
ATC — D10AX02; S01AX06.
ATC Vet — QD10AX02; QS01AX06.

Pharmacopoeias.

In US.

USP 31

(Resorcinol Monoacetate). A pale yellow or amber, viscous liquid with a faint characteristic odour. Sparingly soluble in water; soluble in alcohol and in most organic solvents. A saturated solution in water is acid to litmus. Store in airtight containers. Protect from light.

💊 Adverse Effects, Treatment, and Precautions

Resorcinol is a mild irritant and may result in skin sensitisation. It should not be applied to large areas of the body, for prolonged periods, or in high concentrations, especially in children, as it is absorbed through intact skin as well as broken skin and may interfere with thyroid function or produce methaemoglobinaemia. Resorcinol may produce hyperpigmentation in patients with dark skins and may darken light-coloured hair. Systemic toxic effects of resorcinol are similar to those of phenol and are treated accordingly but convulsions may occur more frequently.

Abnormal coloration.

Resorcinol could cause green discoloration of the urine.1
1. Karlstrand J. The pharmacist and the ostomate. J Am Pharm Assoc 1977; NS17: 735–8.

💊 Uses and Administration

Resorcinol has keratolytic properties and has been used, usually with sulfur, in topical preparations for the treatment of acne and seborrhoeic skin conditions, although other treatments are generally preferred. Resorcinol has also been used in preparations for the treatment of anorectal disorders often complexed with bismuth compounds. Resorcinol monoacetate has been used similarly but may provide a milder action with a longer duration.

Dentistry.

Resorcinol powder added incrementally to a few drops of formaldehyde 40% solution to saturation and polymerised using 1 or 2 drops of sodium hydroxide 10% solution produces a hard red material, known as "Russian Red". This resin has been used in dentistry in eastern Europe, Russia, and China. Zinc oxide or barium sulfate is often added to the mixture before polymerisation to make it radio-opaque.1
1. Schwandt NW, Gound TG. Resorcinol-formaldehyde resin “Russian Red” endodontic therapy. J Endod 2003; 29: 435–7.

💊 Preparations

BPC 1973: Magenta Paint; USP 31: Carbol-Fuchsin Topical Solution; Compound Resorcinol Ointment; Resorcinol and Sulfur Topical Suspension.

Proprietary Preparations

Chile: Dermobarrina; USA: Castel. Multi-ingredient: Arg.: Acnomel†; Acnoxin; Bifena; Callicida†; Coltix†; Controlacne; Cutidermin†; Dermo Vagisil Crema; Ecnagel; Ecnagel E; Farmigras; Histidanol†; Nemegel†; Pinklot; Suffisance; Austral.: Acne & Pimple Gel†; Eskamel; Seborrol†; Austria: Wisamt†; Belg.: Synthol; Braz.: Pantevit; Canad.: Clearasil Acne Control; Clearasil Acne Cream; Lanacane Medicated Cream; Mazon Medicated Cream; Vagisil; Chile: Acnaid†; Antiacne†; Dermac Crema; Fr.: Anaxeryl; Bain de Bouche Lipha; Gelictar Fort; Nestosyl; Osmotol; Squaphane S; Synthol; Ger.: Jaikal†; Wisamt N†; Hong Kong: Acne-Aid; Hung.: Glycosept; Indon.: Bioacne; Rosal; Verile; Irl.: AnugesicHC; Anusol-HC; Israel: Acnex†; Pitrisan; Ital.: Anusol; Blefarolin; Fucsina Fenica; Labocaina; Rinantipiol†; Malaysia: Acne-Aid; Mex.: Crema Axel†; Dermac; Dermocare; Dermoscalp; Jabon del Tio Nacho; Shampoo del Tio Nacho; NZ: Egomycol†; Lanacane; Seborrol†; Pol.: Afronis; Hemorectal; Pigmentum Castellani; Port.: Edoltar†; Resodermil; Rus.: Neo-Anusol (Нео-анузол); S.Afr.: Anugesic; Eskamel; Singapore: Acne Clear; AcneAid; Spain: Acnisdin; Dermomycose Liquido; Milrosina; Resorborina; Switz.: Clabin; Euproctol; Lotio decapans; Thai.: Anusol; Zema; Turk .: Buco Bleu; UK: Eskamel; USA: Acnomel; Bensulfoid; Bicozene; Castaderm; Dermarest; Fungi-Nail; Heal Aid Plus; RA Lotion; Rezamid; Sulforcin; Unguentine Maximum Strength; Vagisil; Venez.: Alderil†; Klenyl.
Published January 12, 2019.