Pyrithione Zinc

(BAN, USAN, rINN)
Pyrithione Zinc Chemical formula
Synonyms: Çinko Pirition; Piritiona cíncica; Piritiona de zinc; Pyrithione Zincique; Pyrithionum Zincicum; Zinc 2-Pyridinethiol 1-Oxide; Zinc Pyridinethione. Bis[1-hydroxypyridine-2(1H)-thionato]zinc.
Cyrillic synonym: Пиритион Цинк.

💊 Chemical information

Chemical formula: C10H8N2O2S2Zn = 317.7.
CAS — 13463-41-7.
ATC — D11AX12.
ATC Vet — QD11AX12.

💊 Profile

Pyrithione zinc has bacteriostatic and fungistatic properties. It is used similarly to selenium sulfide in usual concentrations of 1 to 2% in the control of seborrhoeic dermatitis and dandruff. It is an ingredient of some proprietary shampoos. It has also been used in the treatment of pityriasis versicolor. Pyrithione magnesium has also been used.

Effects on the nervous system.

Peripheral neuritis with paraesthesia and muscle weakness in a patient was associated with the prolonged use of a shampoo containing pyrithione zinc 2%.1The muscle weakness had disappeared 3 months after stopping the shampoo and 2 years later the paraesthesia had improved by about 75%. Studies in animals had found signs of neurotoxicity after oral doses of pyrithione zinc but whereas absorption after topical application was found to be 13% for pyrithione sodium it was less than 1% for pyrithione zinc.2
1. Beck JE. Zinc pyrithione and peripheral neuritis. Lancet 1978; i: 444
2. Parekh CK. Zinc pyrithione and peripheral neuritis. Lancet 1978, i: 940.

💊 Preparations

Proprietary Preparations

Arg.: Aeroseb; Amenite Cap†; Antiminth; Dermazinc; Hairplus; Min Huil; Skin-Cap; ZNP†; Austral.: Dan-Gard; Dandruff Control Pert 2 in 1; Austria: Desquaman; Canad.: Advance†; Brylcreem Anti-Dandruff; DanGard; Dandruff Shampoo plus Conditioner†; Denorex Everyday; Hair & Scalp†; Head & Shoulders; Lander Dandruff Control†; Out of Africa; Pert Plus; Satinique Anti-Dandruff†; Scott Dandruff Shampoo; Shaklee Dandruff Control†; Shampooing Anti-Pelliculaire; Solve Dandruff; Techniques AntiDandruff†; ZNP; ZP 11†; Chile: Biolane; DHS Zinc; Skin Cap; ZNP; Denm.: Skaelud; Fr.: Ducray Antipelliculaire†; Provegol; Shampooing Traitant Antipelliculaire†; ZNP; Ger.: De-squaman N†; Gr.: Daohair-S; Israel: Desquaman; Ital.: Rivescal ZPT; Shampoo SDE Zinc†; ZNP; Mex.: Pirimed; ZNP; Port.: ZP Dermil; Rus.: Freederm Zinc (Фридерм Цинк); Skin-Cap (Скин-Кап); Spain: Zincation; Turk.: Zetion; Zintion; USA: DHS Zinc; Head & Shoulders; Skin Cure; Zincon; ZNP; Venez.: Albepir; Blue Caps; Caduzinc†; Denorex Original†; Pirimed. Multi-ingredient: Arg.: Aeroseb; Molnia; Neo Moldava†; Austral.: Fongitar; Braz.: Fisohex II; Canad.: Multi-Tar Plus; X-Seb Plus; Z-Plus; Chile: Node DS; Cz.: Polytar AF; Fr.: Item Alphakeptol; Kelual DS; Klorane Shampooing Antipelliculaire; Node DS; Node P; Hong Kong: Fongitar; MultiTar ; Hung.: Polytar AF; Squa-med; India: Hyphoral; Scalpe; Ital.: Biothymus DS; Derman-Shampoo AF†; Keto Z; Ketomousse; Kevis; Malaysia: Ketoplus; NZ: Fongitar†; Philipp.: Fongitar; Scalpex; Pol.: Polytar AF; Port.: All Pecium†; Alpha Septol; Alphakeptol†; Fongitar; Rus.: Keto Plus (Кето Плюс); S.Afr.: Fongitar; Singapore: Fongitar; pHisoHex Reformulated†; Spain: Zincation Plus; Switz.: Sebo Shampooing; Sebo-Soufrol; Squa-med; Thai.: Fongitar; Turk.: Pirdolin; Seboreks; Sedolin; UK: Polytar AF; USA: X-Seb Plus; Xolegel Duo; Venez.: Node DS; Pelset Plus.
Published January 11, 2019.