Octinoxate

(USAN, rINN)
Octinoxate Chemical formula
Synonyms: Octinoxato; Octinoxatum; Octyl methoxycinnamate. 2-Ethylhexylp-methoxycinnamate; 3-(4-Methoxylphenyl)-2-propenoic acid 2-ethylhexyl ester.
Cyrillic synonym: Оциноксат.

Chemical information

Chemical formula: C18H26O3 = 290.4.
CAS — 5466-77-3.
ATC — D02BA02.
ATC Vet — QD02BA02.

Pharmacopoeias.

In US.

USP 31

(Octinoxate). Pale yellow oil. Insoluble in water. Store in airtight containers at a temperature of 8° to 15°.

Profile

Octinoxate, a substituted cinnamate, is used by topical application as a sunscreen. Cinnamate sunscreens effectively absorb light throughout the UVB range but absorb little or no UVA light. Cinnamate sunscreens may therefore be used to prevent sunburn but are unlikely to prevent drug-related or other photosensitivity reactions associated with UVA light; combination with a benzophenone may give some added protection against such photosensitivity. Cinnamates may occasionally produce photosensitivity reactions.
Published January 03, 2019.