Monobenzone

(rINN)
Monobenzone Chemical formula
Synonyms: Benoquina; Hydroquinone Monobenzyl Ether; Monobenzona; Monobenzonum. 4-Benzyloxyphenol.
Cyrillic synonym: Монобензон.

💊 Chemical information

Chemical formula: C13H12O2 = 200.2.
CAS — 103-16-2.
ATC — D11AX13.
ATC Vet — QD11AX13.

Pharmacopoeias.

In US.

USP 31

(Monobenzone). Store at a temperature not exceeding 30° in airtight containers. Protect from light.

💊 Adverse Effects and Precautions

Monobenzone may cause skin irritation and sensitisation. In some patients this is transient and the drug need not be withdrawn. In others, an eczematous sensitisation may occur. Excessive depigmentation may occur even beyond the areas under treatment and may produce unsightly patches. Monobenzone frequently produces permanent depigmentation and should not be used as a substitute for hydroquinone.

💊 Interactions

Agalsidase.

For the recommendation that monobenzone not be used with agalsidase alfa or beta.

💊 Uses and Administration

Monobenzone has actions similar to those of hydroquinone but in some patients it also produces extensive and selective destruction of melanocytes. It is used locally for final, permanent depigmentation of normal skin in extensive vitiligo. Monobenzone is not recommended for freckling, chloasma, or hyperpigmentation following skin inflammation or due to photosensitisation after the use of certain perfumes. It has no effect on melanomas or pigmented naevi. For vitiligo a cream containing monobenzone 20% is applied to the affected areas two or three times daily until a satisfactory response is obtained, and thereafter as necessary, usually about twice weekly. Depigmentation only becomes apparent when the preformed melanin pigments have been lost with the normal sloughing of the stratum corneum and this may take several months. If, however, no improvement is noted after 4 months, treatment should be stopped. Excessive exposure to sunlight should be avoided during treatment. After depigmentation the skin will be sensitive for the rest of the patient’s life and a sunscreen must be used during sun exposure.

💊 Preparations

USP 31: Monobenzone Cream.

Proprietary Preparations

Canad.: Benoquin; India: Benoquin†; USA: Benoquin.
Published January 01, 2019.