Mequinol

(USAN, rINN)
Mequinol Chemical formula
Synonyms: BMS-181158; p-Guaiacol; 4-HA; 4-Hidroxianisol; HQMME; Hydroquinone Monomethyl Ether; p-Hydroxyanisole; Hydroxyquinone Methyl Ether; Méquinol; Mequinolum; Metoxifenol; p-Metoxifenol. 4-Methoxyphenol.
Cyrillic synonym: Меквинол.

💊 Chemical information

Chemical formula: C7H8O2 = 124.1.
CAS — 150-76-5.
ATC — D11AX06.
ATC Vet — QD11AX06.

💊 Profile

Mequinol is used similarly to hydroquinone, in concentrations of up to 20%, in the treatment of hyperpigmentation. A preparation containing mequinol 2% with tretinoin 0.01% is used for the treatment of solar lentigines (liver spots).

Adverse effects.

A report of severe reversible irregular hypopigmentation of the hands, arms, neck, and legs in a West Indian woman who applied a bleaching wax containing mequinol for 2 to 3 months to lighten the colour of her skin.1
1. Boyle J, Kennedy CTC. British cosmetic regulations inadequate. BMJ 1984; 288: 1998–9.

Pigmentation disorders.

References.
1. Fleischer AB, et al. The combination of 2% 4-hydroxyanisole (mequinol) and 0.01% tretinoin is effective in improving the appearance of solar lentigines and related hyperpigmented lesions in two double-blind multicenter clinical studies. J Am Acad Dermatol 2000; 42: 459–67
2. Njoo MD, et al. Depigmentation therapy in vitiligo universalis with topical 4-methoxyphenol and the Q-switched ruby laser. J Am Acad Dermatol 2000; 42: 760–9
3. Ortonne JP, et al. Safety and efficacy of combined use of 4-hydroxyanisole (mequinol) 2%/tretinoin 0.01% solution and sunscreen in solar lentigines. Cutis 2004; 74: 261–4
4. Jarratt M. Mequinol 2%/tretinoin 0.01% solution: an effective and safe alternative to hydroquinone 3% in the treatment of solar lentigines. Cutis 2004; 74: 319–22
5. Draelos ZD. The combination of 2% 4-hydroxyanisole (mequinol) and 0.01% tretinoin effectively improves the appearance of solar lentigines in ethnic groups. J Cosmet Dermatol 2006; 5: 239–44.

💊 Preparations

Proprietary Preparations

Austria: Leucobasal; Braz.: Leucodin; Fr.: Any; Leucodinine B; Gr.: Leucodinine-M; Spain: Novo Dermoquinona. Multi-ingredient: Canad.: Solage†; USA: Solage.
Published December 25, 2018.