Liarozole Hydrochloride

(BANM, USAN, rINNM)
Synonyms: Hidrocloruro de liarozol; Liarozole, Chlorhydrate de; Liarozoli Hydrochloridum; R-75251.
Cyrillic synonym: Лиарозола Гидрохлорид.

Chemical information

Chemical formula: C17H13ClN4, HCl = 345.2.
CAS — 145858-50-0.

Profile

Liarozole, an imidazole analogue, increases plasma and cutaneous retinoic acid concentrations through inhibition of cytochrome P450 isoenzymes involved in retinoic acid catabolism. It is under investigation for the management of ichthyoses and psoriasis.
1. Bhushan M, et al. Oral liarozole in the treatment of palmoplantar pustular psoriasis: a randomized, double-blind, placebo-controlled study. Br J Dermatol 2001; 145: 546–53
2. Lucker GPH, et al. Topical liarozole in ichthyosis: a doubleblind, left-right comparative study followed by a long-term open maintenance study. Br J Dermatol 2005; 152: 566–9
3. Verfaille CJ, et al. Oral liarozole vs. acitretin in the treatment of ichthyosis: a phase II/III multicentre, double-blind, randomized, active-controlled study. Br J Dermatol 2007; 156: 965–73.
Published December 22, 2018.