Dihydroxyacetone

(BAN, rINN)
Dihydroxyacetone Chemical formula
Synonyms: DHA; Dihidroxiacetona; Ketotriose. 1,3-Dihydroxypropan-2one.
Cyrillic synonym: Дигидроксиацетон.

💊 Chemical information

Chemical formula: C3H6O3 = 90.08.
CAS — 96-26-4.

Pharmacopoeias.

In US.

USP 31

(Dihydroxyacetone). A white to off-white crystalline powder. The monomeric form is freely soluble in water, in alcohol, and in ether; the dimeric form is freely soluble in water, soluble in alcohol, and sparingly soluble in ether. A 5% solution in water has a pH between 4.0 and 6.0. Store at a temperature of 8° to 15° in airtight containers.

💊 Adverse Effects and Precautions

Skin irritation from dihydroxyacetone occurs rarely; rashes and allergic dermatitis have been reported. Contact with eyes, abraded skin, and clothing should be avoided.

💊 Uses and Administration

Application to the skin of preparations containing dihydroxyacetone slowly produces a brown coloration similar to that caused by exposure to the sun, probably due to a reaction with the amino acids of the skin. A single application may give rise to a patchy appearance; progressive darkening of the skin results from repeated use until a point is reached when the maximum effect is achieved. If the treatment is stopped the colour starts to fade after about 2 days and disappears completely within 8 to 14 days as the external epidermal cells are lost by normal attrition. Preparations usually contain 5% of dihydroxyacetone and have been used to camouflage vitiligo or to produce an artificial suntan. Some preparations include sunscreens since the pigmentation produced gives no protection against sunburn.

💊 Preparations

Proprietary Preparations

Arg.: Autohelios†; Eurocolor Sin Sol; Ikx Autobronceante; Leche Autobronceadora†; Lelco sin Sol; Austral.: Le Tan Fast Extra Dark†; Le Tan Fast Self Tan†; Vitadye; Braz.: Autohelios; Chile: Fotoprotectores; Leche Autobronceadora Cara Y Cuerpo; Neutrogena Bronceador; ROC Minesol Bronze; Sans Soleil Skin Ceuticals†; Malaysia: Vitadye†; Mex.: Dermacrom; USA: Chromelin Complexion Blender. Multi-ingredient: Arg.: Fotosol Ultra Autobronceante; Polysianes Autobronceante; Austral.: Le Tan Fast Plus†; Braz.: Sunmax Autobronzeador; UK: ViTicolor; USA: QT.
Published November 26, 2018.