Crotamiton Chemical formula
Synonyms: Crotam; Crotamitón; Crotamitonum; Krotamiton; Krotamitonas; Krotamitoni. N-EthylNo-tolylcrotonamide; N-Ethylcrotonootoluidide; N-EthylN-(2-methylphenyl)-2-butenamide.
Cyrillic synonym: Кротамитон.

💊 Chemical information

Chemical formula: C13H17NO = 203.3.
CAS — 483-63-6.
ATC Vet — QP53AX04.


In Chin., Eur., and US.

Ph. Eur. 6.2

(Crotamiton). A colourless or pale yellow oily liquid. It solidifies partly or completely at low temperatures. It is mainly the (E)-isomer, with not more than 15% of the (Z)-isomer. Slightly soluble in water; miscible with alcohol. Protect from light.

USP 31

(Crotamiton). A colourless to slightly yellowish oil with a faint amine-like odour. It is a mixture of cis- and trans-isomers. Soluble in alcohol and in methyl alcohol. Store in airtight containers. Protect from light.

💊 Adverse Effects and Precautions

Topical use of crotamiton occasionally causes irritation. There have been rare reports of hypersensitivity reactions. Crotamiton should not be used in patients with acute exudative dermatitis. It should not be applied near the eyes, mouth, or other mucous membranes or on excoriated skin. Ingestion of crotamiton may cause burning and irritation of oral, oesophageal, and gastric mucosa with nausea, vomiting, and abdominal pain.


A 23-year-old woman developed tonic-clonic seizures, requiring treatment with diazepam, after ingestion of a crotamiton emulsion.1 Other hospital treatment included gastric lavage, activated charcoal, and metoclopramide. Crotamiton was detected in serum at a concentration of 34 micrograms/mL and was also detectable with several metabolites in the urine. Reference was also made to a report of a 2 ⁄ -month-old child who had developed pallor and cyanosis after excessive dermal application of a crotamiton cream.
1. Meredith TJ, et al. Crotamiton overdose. Hum Exp Toxicol 1990; 9: 57.

💊 Uses and Administration

Crotamiton is used as an antipruritic, although its value is considered uncertain (see also below). It is applied as a 10% cream or lotion 2 or 3 times daily; children aged less than 3 years may receive one application daily. Crotamiton has also been used as an acaricide in the treatment of scabies but other more effective drugs are usually preferred. The 10% cream or lotion is applied, after first bathing and drying, to the whole of the body-surface below the chin, particular attention being paid to body folds and creases. A second application should be applied 24 hours later but it may need to be used once daily up to a total of 5 days to be effective.


A double-blind study in 31 patients1 found that 10% crotamiton lotion was no more effective an antipruritic than its vehicle.
1. Smith EB, et al. Crotamiton lotion in pruritus. Int J Dermatol 1984; 23: 684–5.

💊 Preparations

BP 2008: Crotamiton Cream; Crotamiton Lotion; USP 31: Crotamiton Cream.

Proprietary Preparations

Austral.: Eurax; Austria: Eurax; Belg.: Eurax; Canad.: Eurax; Chile: Eurax; Fr.: Eurax; Ger.: Crotamitex; Eraxil; Hong Kong: Eurax; Eurosin; Marax; India: Crotorax; Irl.: Eurax; Israel: Eurax; Scabicin; Ital.: Eurax; Malaysia: Crotorax; Eurax; Moz-Bite; Mex.: Eurax; Norw.: Eurax; NZ: Eurax; Philipp.: Congen; Eurax; Scabirax; Port.: Eurax; Scabicin; S.Afr.: Eurax; Singapore: Eurax; Moz-Bite; Spain: Euraxil; Switz.: Eurax; UK: Eurax; USA: Eurax; Venez.: Crotanol. Multi-ingredient: Arg.: Anastim con RTH; Empecid Pie; Fr.: Acarcid†; Kelual DS; Triazol†; India: Crotorax-HC; Irl.: Eurax-Hydrocortisone; Israel: Duo-Scabil; Jpn: Una A Gel; Malaysia: Crotamiton H; UK: EuraxHydrocortisone; Venez.: Kertyol.
Published November 22, 2018.