Centella

(BAN, rINN)
Synonyms: Azijine˙scentele˙sžole˙; Ázsiai gázlófu˝; Centellae asiaticae herba; Herba Centellae; Hidrocótilo; Hydrocotyle; Indian Pennywort; Nat’ centely asijské; Rohtosammakonputki; Sallatsspikblad.
Cyrillic synonym: Центелла Азиатская (.

💊 Chemical information

) CAS — 18449-41-7 (madecassic acid); 464-92-6 (asiatic acid); 16830-15-2 (asiaticoside).

Pharmacopoeias.

In Chin. and Eur..

Ph. Eur. 6.2

(Centella). The dried, fragmented aerial parts of Centella asiatica. It contains not less than 6% of total triterpenoid derivatives, expressed as asiaticoside, calculated with reference to dried drug. Protect from light.

💊 Profile

Centella contains madecassic acid, asiatic acid, and asiaticoside. It has been used topically and orally in the management of wounds, ulcers, and keloid scars. The names gotu kola, gotu cola, and gota kola are used for Centella asiatica (=Hydrocotyle asiatica) in herbal medicine. Centella is also used in homoeopathic medicine.

Adverse effects.

Contact dermatitis has been reported with the topical use of centella.1 There is also a report of 3 cases of hepatotoxicity associated with ingestion of centella, all presenting with jaundice, painful hepatomegaly, and granulomatous hepatitis with areas of necrosis.2
1. Gonzalo Garijo MA, et al. Allergic contact dermatitis due to Centella asiatica: a new case. Allergol Immunopathol (Madr) 1996; 24: 132–4
2. Jorge OA, Jorge AD. Hepatotoxicity associated with the ingestion of Centella asiatica. Rev Esp Enferm Dig 2005; 97: 115–24.

💊 Preparations

Proprietary Preparations

Arg.: Gotu Kola†; Pertusan†; Remiderm†; Austria: Madecassol; Belg.: Madecassol; Braz.: Centelax; Centella-Vit; Chile: Celulase; Celulase Plus; Centabel; Escar T; Madecassol; Fr.: Madecassol; Gr.: Madecassol; Hong Kong: Madecassol; Indon.: Fitocassol; Lanakeloid; Madecassol; Ital.: Centellase; Malaysia: Lanakeloid; Mex.: Madecassol; Port.: Madecassol; Singapore: Centellase; Centica; Spain: Blastoestimulina; Thai.: Madecassol†; Turk.: Madecassol; Venez.: Litonate; Madecassol; Triffadiane†. Multi-ingredient: Arg.: Celu-Atlas; Centella Asiatica Compuesta; Centella Asiatica Diates; Centella Asiatica Vital; Centella Incaico; Centella Queen Complex; Centella Queen Reductora; Centellacrom; Centellase de Centella Queen; Centellase Gel; Clevosan; Enlinea†; Estri-Atlas; Garcinol Max; Ginal Cent; Ginkan; Herbaccion Celfin; Lidersoft†; Linfol Cicatrizante; Lociherp Liposomas Antiage; Lociherp Liposomas Vitaminado; Mailen; Moragen; Nio Marine; No-Gras; Ovumix; Pentol; Redudiet; Septigyn; Vagicural Plus; Venoful; VNS 45; Austral.: Extralife Leg-Care; Braz.: Composto Anticelulitico†; Composto Emagrecedor†; Derm’attive 10†; Emagrevit†; Chile: Celulase Con Neomicina; Cicapost; Dermaglos Plus†; Escar T-Neomicina; Madecassol Neomicina†; Ureadin Rx DB; Fr.: Calmiphase†; Cicatridine; Fadiamone; Madecassol Neomycine Hydrocortisone†; Indon.: Lanakeloid-E; Venos; Ital.: Angiorex Complex; Angioton; Angiovein; Capill; Capill Venogel; Centella Complex; Centeril H; Dermilia Flebozin; Emmenoiasi; Flebo-Si; Flebofort; Flebolider; Gelovis; Levital Plus; Neomyrt Plus; Osmogel; Pik Gel; Varicofit; Venactive; Malaysia: Total Man†; Mex.: Madecassol C; Madecassol N; Philipp.: Memori Plus; Memory DD; Ruflex; Port.: Antiestrias; Spain: Blastoestimulina; Cemalyt; Nesfare; Venez.: Celyth’s.
Published November 17, 2018.