Azelaic Acid

Azelaic Acid Chemical formula
Synonyms: Acide azélaïque; Ácido azelaico; Acidum azelaicum; Anchoic acid; Atselaiinihappo; Azelaik Asit; Azelainsyra; Lepargylic acid; ZK62498. Nonanedioic acid; Heptane-1,7-dicarboxylic acid.
Cyrillic synonym: Азелаиновая Кислота.

💊 Chemical information

Chemical formula: C9H16O4 = 188.2.
CAS — 123-99-9.
ATC — D10AX03.
ATC Vet — QD10AX03.

💊 Adverse Effects and Precautions

Topical application of azelaic acid may produce a transient skin irritation such as burning, stinging, pruritus, dryness, and scaling. It is usually mild and disappears on continued treatment, but in a few patients the irritation may persist, requiring reduced frequency of application or temporary suspension of treatment. There have been rare reports of hypopigmentation, rash, and photosensitivity. Azelaic acid should not be applied to the eyes, mouth, or other mucous membranes.

💊 Uses and Administration

Azelaic acid inhibits the growth of Propionibacterium
spp. and reduces keratinisation. It is used in the topical treatment of mild to moderate inflammatory acne and for the inflammatory papules and pustules of mild to moderate rosacea. It has also been tried in hyperpigmentary skin disorders such as melasma, and in malignant melanoma. In the treatment of acne azelaic acid is applied twice daily for up to 6 months as a 20% cream or 15% gel. Improvement usually occurs within four weeks. For the treatment of mild to moderate rosacea, a 15% gel should be applied to the affected area twice daily for a period of up to 12 weeks. Improvement usually occurs in 4 to 8 weeks.
1. Fitton A, Goa KL. Azelaic acid: a review of its pharmacological properties and therapeutic efficacy in acne and hyperpigmentary skin disorders. Drugs 1991; 41: 780–98
2. Breathnach AS. Melanin hyperpigmentation of skin: melasma, topical treatment with azelaic acid, and other therapies. Cutis 1996; 57 (suppl): 36–45
3. Elewski B, Thiboutot D. A clinical overview of azelaic acid. Cutis 2006; 77 (suppl): 12–16
4. Del Rosso JQ. The use of topical azelaic acid for common skin disorders other than inflammatory rosacea. Cutis 2006; 77 (suppl): 22–4
5. Liu RH, et al. Azelaic acid in the treatment of papulopustular rosacea: a systematic review of randomized controlled trials. Arch Dermatol 2006; 142: 1047–52.

💊 Preparations

Proprietary Preparations

Arg.: Cutacelan; Austral.: Finacea; Skinoren; Austria: Skinoren; Belg.: Skinoren; Braz.: Azelan; Dermizan; Cz.: Aknoren; Skinoren; Denm.: Finacea; Skinoren; Fin.: Skinoren; Fr.: Finacea; Skinoren; Ger.: Skinoren; Gr.: Alenzantyl; Azedose; Azelac; Azelaxine; Azelderm; Cevigen; Chemilaic†; Exazen; Forcilen†; Kenedril; Noreskin; Opilet; Prevolac†; Skinoren; Sonalent; Zelicrema; Zorkenil; Zumilin; Hong Kong: Qualicren; Qualilaic; Skinoren; Hung.: Skinoren; Indon.: Aza 20; Skinoren; Zelface; Zeliris; Irl.: Skinoren; Israel: Skinoderm; Ital.: Acnezaic†; Finacea; Neocutis; Skinoren; Malaysia: Skinoren; Mex.: Cutacelan†; Finacea; Norw.: Finacea; Skinoren; NZ: Skinoren; Philipp.: Skinoren; Pol.: Acne-Derm; Hascoderm; Skinoren; Port.: Dermazil; Finacea; Skinoren; Rus.: Skinoren (Скинорен); S.Afr.: Skinoren; Singapore: Skinoren; Spain: Finacea; Skinoren; Zeliderm; Swed.: Finacea; Skinoren; Switz.: Skinoren; Thai.: Skinoren; Turk.: Azelderm; Skinoren; UK: Finacea; Skinoren; USA: Azelex; Finacea; Finevin; Venez.: Cutacelan. Multi-ingredient: Austral.: Acnederm Medicated; Hong Kong: Acnederm; Ital.: Zeroac; Malaysia: Acnederm Lotion; NZ: Acnederm; Singapore: Acnederm.
Published November 06, 2018.