Ammoniated Mercury

(USAN, rINN)
Synonyms: Aminomercuric Chloride; Hydrargyri Aminochloridum; Hydrargyrum Amidochloratum; Hydrargyrum Ammoniatum; Hydrargyrum Praecipitatum Album; Mercuric Amidochloride; Mercuric Ammonium Chloride; Mercurio amoniacal; Mercury Amide Chloride; Mercury Aminochloride; Precipitado blanco (de mercurio); White Precipitate.
Cyrillic synonym: Хлористый Меркураммоний.

💊 Chemical information

Chemical formula: NH2HgCl = 252.1.
CAS — 10124-48-8.
ATC — D08AK01.
ATC Vet — QD08AK01.

Pharmacopoeias.

In US.

USP 31

(Ammoniated Mercury). A white amorphous powder or pulverulent pieces; odourless. It is stable in air, but darkens on exposure to light. Insoluble in water and in alcohol; readily soluble in warm hydrochloric, nitric, and acetic acids. Protect from light.

💊 Profile

Ammoniated mercury was formerly used topically in the treatment of skin infections and psoriasis but the use of such mercurial preparations is generally deprecated. Frequent or prolonged application to large areas or to broken skin or mucous membranes can cause mercury poisoning and use on infants has produced acrodynia (pink disease). Ammoniated mercury is also a potent sensitiser and can produce allergic reactions.

Effects on the kidneys.

Of 60 patients who were found to have nephrotic syndrome, 32 had used skin-lightening creams containing 5 to 10% of ammoniated mercury.1 Concentrations of mercury in the urine of these patients were up to 250 nanograms/mL compared with a usual upper limit of 80 nanograms/mL. Of 26 patients followed up for up to 2 years, 13 had no remission or response to treatment; 6 of these had used skin lighteners.
1. Barr RD, et al. Nephrotic syndrome in adult Africans in Nairobi. BMJ 1972; 2: 131–4.

💊 Preparations

Proprietary Preparations

Multi-ingredient: Cz.: Homeovox; Hung.: Dermaforine†.
Published December 27, 2018.