Aluminium Chlorohydrate

(USAN)
Synonyms: Aluminio, clorohidróxido de; Aluminium Chlorhydrate; Aluminium Chloride Hydroxide Hydrate; Aluminum Chlorhydroxide; Aluminum Chloride Hydroxide Hydrate; Aluminum Chlorohydrate siklorür; Basic Aluminium Chloride.
Cyrillic synonym: Алюминия Хлорогидрат.

💊 Chemical information

Chemical formula: Al25Cl,xH2O.
CAS — 1327-41-9 (anhydrous aluminium chlorohydrate).
ATC — D09AA08; M05BX02.
ATC Vet — QD09AA08; QM05BX02.

Pharmacopoeias.

In US. US also includes a range of compounds based on aluminium chlorohydrate. These are:
aluminium dichlorohydrate and sesquichlorohydrate
the polyethylene glycol (macrogol) complexes and propylene glycol complexes of aluminium chlorohydrex, aluminium dichlorohydrex, and aluminium sesquichlorohydrex
the tri-, tetra-, penta-, and octachlorohydrates of aluminium zirconium and their respective glycine derivatives.

USP 31

(Aluminum Chlorohydrate). A 15% w/w solution in water has a pH of 3.0 to 5.0

💊 Profile

Aluminium chlorohydrate is used similarly to aluminium chloride in hyperhidrosis. Single-ingredient products for hyperhidrosis generally have a concentration in the range of 10 to 25%. Aluminium chlorohydrate is also included in a variety of dermatological preparations for its astringent and antiperspirant properties.

Aluminium toxicity.

Bone pain, extreme fatigue, and raised aluminium concentrations in a woman with normal renal function were attributed to the use of an antiperspirant cream containing aluminium chlorohydrate 20%. She had been applying about 1 g of cream to each underarm daily for 4 years. Within 8 months of stopping the antiperspirant, plasma-aluminium concentrations had returned to normal and symptoms had resolved.1
1. Guillard O, et al. Hyperaluminemia in a woman using an aluminum-containing antiperspirant for 4 years. Am J Med 2004; 117: 956–9.

💊 Preparations

USP 31: Aluminum Chlorohydrate Solution; Aluminum Dichlorohydrate Solution; Aluminum Sesquichlorohydrate Solution; Aluminum Zirconium Octachlorohydrex Gly Solution; Aluminum Zirconium Pentachlorohydrate Solution; Aluminum Zirconium Pentachlorohydrex Gly Solution; Aluminum Zirconium Tetrachlorohydrate Solution; Aluminum Zirconium Tetrachlorohydrex Gly Solution; Aluminum Zirconium Trichlorohydrate Solution; Aluminum Zirconium Trichlorohydrex Gly Solution.

Proprietary Preparations

Arg.: Bromhistop; Daewo†; Normoskin†; Sodorant; Canad.: Roll-On†; Scholl Dry Antiperspirant Foot Spray†; Chile: Hansaplast Footcare; Hidrofugal; Fr.: pM; Spirial; Ger.: Phosphonorm; Israel: Aloxan Derma; Ital.: Spirial; Mex.: Skin Dry; NZ: Neat Effect; Neat Feat; Neat One; Neat Touch; Port.: Dermagor-Antitranspirante; Lambda; Switz.: Alopon†; Gelsica; Phosphonorm; Sansudor; Turk.: Kursept; Terkur; UK: Chiron Barrier Cream; USA: Bromi-Lotion. Multi-ingredient: Arg.: Neobitiol; Sodorant; Ublosid†; Austral.: NappyMate†; Neo-Medrol; Austria: Sulgan 99; Canad.: Medrol Acne Lotion; Neo-Medrol Acne; Chile: Hidrofugal; Hidrofugal Forte; Lady Fittig†; Uriage Desodorante Tri-Actif; Fin.: Neo-Medrol comp†; Fr.: Spirial; Ger.: Ansudor†; Epipak†; Hong Kong: Neo-Medrol Acne; Indon.: Betiga; Israel: Fungimon; Neo-Medrol; Pedisol; Ital.: Medrol Lozione Antiacne†; S.Afr.: Neo-Medrol; Spain: Hongosan; Moderin Acne†; USA: Breezee Mist Foot Powder ; Ostiderm.
Published October 28, 2018.