Aluminium Chloride

(BAN, USAN)
Synonyms: Aliuminio chloridas heksahidratas; Alumiinikloridiheksahydraatti; Aluminii chloridum hexahydricum; Aluminio, cloruro de; Aluminium Chloratum; Aluminium (chlorure d’) hexahydraté; Alumínium-klorid-hexahidrát; Aluminiumkloridhexahydrat; Aluminum Chloride; Chlorid hlinitý hexahydrát; Cloreto de Aluminio; Cloruro de Aluminio; Glinu chlorek. Aluminium chloride hexahydrate.
Cyrillic synonym: Алюминия Хлорид.

💊 Chemical information

Chemical formula: AlCl3,6H2O = 241.4.
CAS — 7446-70-0 (anhydrous aluminium chloride); 778413-6 (aluminium chloride hexahydrate).
ATC — D10AX01.
ATC Vet — QD10AX01.

Pharmacopoeias.

In Eur. and US.

Ph. Eur. 6.2

(Aluminium Chloride Hexahydrate). A deliquescent, white or slightly yellow, crystalline powder or colourless crystals. Very soluble in water; freely soluble in alcohol; soluble in glycerol. Store in airtight containers.

USP 31

(Aluminium Chloride). Deliquescent, white or yellowish-white, practically odourless, crystalline powder. Its solutions are acid to litmus. Soluble 1 in 0.9 of water and 1 in 4 alcohol; soluble in glycerol. Store in airtight containers.

💊 Adverse Effects

Aluminium chloride may cause irritation especially if applied to damp skin; this is attributed to the formation of hydrochloric acid.

💊 Uses and Administration

Aluminium chloride has astringent properties and is used in a 20% alcoholic solution as an antiperspirant in the treatment of hyperhidrosis. It is applied to dry skin, usually at bedtime, and is washed off in the morning before the sweat glands are fully active. Initially, it may be applied each night until sweating improves, then less frequently, as required, to maintain efficacy.
1. Scholes KT, et al. Axillary hyperhidrosis treated with alcoholic solution of aluminium chloride hexahydrate. BMJ 1978; 2: 84–5
2. Ellis H, Scurr JH. Axillary hyperhidrosis - topical treatment with aluminium chloride hexahydrate. Postgrad Med J 1979; 55: 868–9.

💊 Preparations

BP 2008: Aluminium Chloride Solution.

Proprietary Preparations

Arg.: Alumpak; Anhidrot†; Drysol; Austral.: Driclor; Odaban†; Chile: Drysol; Xerac AC; Fr.: Driclor; Etiaxil; Ger.: Gargarisma zum Gurgeln; Mallebrin Konzentrat; Hong Kong: Driclor; Irl.: Anhydrol Forte; Driclor; Israel: Anhydrol Forte; Malaysia: Driclor†; Mex.: Drysol; NZ: Hidrosol; Philipp.: Driclor; Pol.: Antidral; S.Afr.: Driclor; Singapore: Driclor; Switz.: Etiaxil; Racestyptine; UK: Anhydrol Forte; Driclor; Odaban; USA: Drysol; Xerac AC. Multi-ingredient: Arg.: Carnot Topico; Chile: Hidrofugal; Hidrofugal Forte; Mex.: Prespir; Switz.: Sansilla; USA: Stypto-Caine.
Published October 26, 2018.