Allantoin

(BAN, USAN)
Allantoin Chemical formula
Synonyms: Alantoin; Alantoína; Alantoinas; Allantoiini; Allantoïne; Allantoinum; Glyoxyldiureide. 5-Ureidohydantoin; 5-Ureidoimidazolidine-2,4-dione; 2,5-Dioxoimidazolidin-4-ylurea.
Cyrillic synonym: Аллантоин; Кордианин.

💊 Chemical information

Chemical formula: C4H6N4O3 = 158.1.
CAS — 97-59-6.

Pharmacopoeias.

In Eur. and US.

Ph. Eur. 6.2

(Allantoin). A white or almost white, crystalline powder. Slightly soluble in water; very slightly soluble in alcohol.

USP 31

(Allantoin). A white crystalline powder. Slightly soluble in water; very slightly soluble in alcohol.

💊 Profile

Allantoin is an astringent and keratolytic. It is present in multiingredient preparations intended for various skin disorders and is also used for its astringent properties in preparations for the treatment of haemorrhoids and other anorectal disorders.

Psoriasis.

In the USA the FDA decided that allantoin should be removed from lotions indicated for psoriasis as it was considered to be ineffective.1
1. Anonymous. Nonprescription drug review gains momentum. WHO Drug Inf 1991; 5: 62.

💊 Preparations

Proprietary Preparations

Canad.: Soothex†; India: Masse; Pol.: Alantan. Multi-ingredient: Arg.: Abanta; Afonisan; Atomoderma A-E; Bushi; Contractubex; Crema Para Paspaduras; Cremsor N; Dermaloe†; Esmedent con Fluor; Euroderm-A; Factor Vit AE; Glossderm†; Lactocrem Bebe; Lociherp Liposomas Vitaminado; Medic†; Mencogrin; Mencogrin AP; Mencogrin†; Pastillas Lorbi; Pastillas Medex; Quem Plus†; Austral.: Acne & Pimple Gel†; Alphosyl; Blistex Medicated Lip Ointment; ER Cream†; Hemocane; Macro Natural Vitamin E Cream; Medi Creme; Medi Pulv; Paxyl; SoloSite; Solyptol†; VR†; Austria: Alphosyl; Contractubex; Rheumex; Ulcurilen; Braz.: Contractubex; Lactrex; Senol†; Vitaderme; Canad.: Blistex Medicated Lip Ointment; Phenoris; Tanac†; Chile: Dermaglos; Dermaglos Plus†; Lactrex†; Nenegloss; Pancrit; Queratopil; Sanoderm; Ureadin 30; Ureadin Rx DB; Ureadin Rx PS; Ureadin Rx RD; Cz.: Brand- und Wundgel†; Contractubex; Jox; Panlid; Fr.: Alpha 5 DS†; Alphosyl†; Cicatryl; Erygine; Hydracuivre; Prebutix; Provictol†; Purif-Ac Emulsion; Purif-Ac Gel; Seborheane; Spirial; Topialyse Fluide; Topialyse Plus; Ger.: Brand- und Wund-Gel Eu Rho†; Contractubex; Ellsurex; Essaven Tri-Complex†; Haemo-Exhirud†; Hydro Cordes; Leukona-Wundsalbe†; Lipo Cordes; Psoriasis-Salbe S†; Ulcurilen N†; Hong Kong: Blistex Lip Ointment†; Burn Cream†; Contractubex; Egoderm; Egopsoryl TA; Medipulv†; Pyodontyl; Hung.: Contractubex; Jox†; India: Contractubex; New Eye Lotion; Shield; Indon.: Mederma; Verile; Israel: Alphosyl HC†; Alphosyl†; Comfrey Plus; Pitrisan; Proctozorin-N; Rekasitin; Ital.: Alphosyle†; Angstrom Viso; Balta-Crin Tar†; Centella Complex; Cerosteril; Cerox†; Ginoxil Ecoschiuma; Keraflex; Sensigel; Sensiquell; Tial-Z; Xerial; Malaysia: Egoderm; Egopsoryl TA; Mex.: Antaderm; Dealan; Glossderm; Hipoglos; Hipoglos Cremoso; Lactrex; Sebryl; Sebryl Plus; Sebstopp; Unguento de la Madre; NZ: Egoderm; Egopsoryl TA; Medipulv; Philipp.: Contractubex; Pol.: Alantan-Plus; Alantavit; Cepan; Contractubex; Dernilan; Mucosit; Pupilek; Septalan; Tointex; Port.: Hidratoderme†; Rus.: Contractubex (Контрактубекс); Hepatrombin (Гепатромбин); Jox (Йокс); S.Afr.: Alphosyl; Arola Rosebalm; Blistex; Clearasil Medicated Facial Cleanser; Singapore: Egoderm; Egopsoryl TA; Erase; Spain: Alphosyl; Amplidermis; Antigrietun; Cortenema; Egarone†; Hepro; Polaramine Topico; Swed.: Alphosyl†; Switz.: Alphastria; Alphosyl†; Alumagall†; Carmol Plus†; Contractubex; Gorgonium; Hepathrombine†; Keli-med; Leniderm†; Lyman; Optrex compresses; Sportium; Unatol; Wulnasin; Thai.: Opplin†; UK: Actinac; Alphosyl HC; Anodesyn; Atopiclair; Vesagex Heelbalm; USA: Alasulf; Anbesol Cold Sore Therapy; Atopiclair; Blistex; Blistex Lip Balm; Deltavac; DIT1-2; Dr Dermi-Heal; Ionax Astringent; Orabase Lip; Tanac; Tanac Dual Core; Venez.: Alantamida; Lactrex.
Published October 22, 2018.