Adapalene Chemical formula
Synonyms: Adapaleeni; Adapalen; Adapalène; Adapaleno; Adapalenum; CD-271. 6-[3-(1-Adamantyl)-4-methoxyphenyl]-2-naphthoic acid.
Cyrillic synonym: Адапален.

💊 Chemical information

Chemical formula: C28H28O3 = 412.5.
CAS — 106685-40-9.
ATC — D10AD03.
ATC Vet — QD10AD03.

💊 Adverse Effects and Precautions

As for Tretinoin.


Anophthalmia and agenesis of the optic chiasma were found in a fetus after termination of pregnancy in a woman who had applied adapalene 0.1% topically from the month before pregnancy until 13 weeks of gestation.1
1. Autret E, et al. Anophthalmia and agenesis of optic chiasma associated with adapalene gel in early pregnancy. Lancet 1997; 350: 339.

💊 Uses and Administration

Adapalene is a naphthoic acid derivative and retinoid analogue with actions similar to those of tretinoin. Adapalene is used in topical treatment of mild to moderate acne where comedones, papules, and pustules predominate. Adapalene is usually applied once daily at night as a 0.1% solution, cream, or gel to skin that has been cleansed and dried; a 0.3% gel is also available. Some patients may require less frequent applications. Other topical preparations that may cause irritation should not be used concurrently. If treatment with topical antibacterials or benzoyl peroxide is required, these should be applied in the morning and adapalene applied at night. There may be apparent exacerbations of the acne during early treatment and a consistent therapeutic response may not be evident for at least 8 weeks. However, if there is no response after 12 weeks, therapy should be reassessed. For use in young children, see below.
1. Brogden RN, Goa KL. Adapalene: a review of its pharmacological properties and clinical potential in the management of mild to moderate acne. Drugs 1997; 53: 511–19
2. Waugh J, et al. Adapalene: a review of its use in the treatment of acne vulgaris. Drugs 2004; 64: 1465–78
3. Pariser DM, et al. Adapalene Study Group. The efficacy and safety of adapalene gel 0.3% in the treatment of acne vulgaris: a randomized, multicenter, investigator-blinded, controlled comparison study versus adapalene gel 0.1% and vehicle. Cutis 2005; 76: 145–51
4. Thiboutot D, et al. Adapalene Study Group. Adapalene gel 0.3% for the treatment of acne vulgaris: a multicenter, randomized, double-blind, controlled, phase III trial. J Am Acad Dermatol 2006; 54: 242–50
5. Thiboutot DM, et al. Adapalene gel, 0.1%, as maintenance therapy for acne vulgaris: a randomized, controlled, investigatorblind follow-up of a recent combination study. Arch Dermatol 2006; 142: 597–602.

Administration in children.

Although not licensed for young children in the UK the BNFC includes adapalene 0.1% cream and gel, applied thinly once daily at night, for neonatal and infantile acne.

💊 Preparations

Proprietary Preparations

Arg.: Adapne; Differin; Panalene; Sinac; Austral.: Differin; Austria: Differin; Belg.: Differin; Braz.: Dalap; Differin; Canad.: Differin; Chile: Adiamil; Differin; Cz.: Differine; Denm.: Redap; Fin.: Differin; Fr.: Differine; Ger.: Differin; Gr.: Adaferin; Hong Kong: Differin; Hung.: Differin; India: Aclene; Adaferin; Adiff; Deriva; Indon.: Evalen; Irl.: Differin; Israel: Adaferin; Ital.: Differin; Malaysia: Differin; Mex.: Adaferin; Neth.: Differin; Norw.: Differin; NZ: Differin; Philipp.: Differin; Klenzit; Pol.: Differin; Port.: Differin; Rus.: Differin (Дифферин); S.Afr.: Differin; Singapore: Differin; Spain: Differine; Swed.: Differin; Switz.: Differin; Thai.: Differin; Turk.: Differin; UK: Differin; USA: Differin; Venez.: Differin. Multi-ingredient: Fr.: Epiduo; India: Deriva-C.
Published October 16, 2018.