Synonyms: Bergapteeni; Bergapten; Bergapteno; Bergaptenum; 5-Metoxipsoraleno; 5-MOP. 4-Methoxy-7H-furo[3,2g]chromen-7-one.
Cyrillic synonym: 5-Метоксипсорален.
💊 Chemical information
Chemical formula: C12H8O4 = 216.2.
CAS — 484-20-8.
ATC — D05BA03.
ATC Vet — QD05BA03.
5-Methoxypsoralen is a photosensitiser with actions similar to those of methoxsalen (above). It may be given orally in the PUVA therapy (see under Methoxsalen, above) of psoriasis and vitiligo. 5-Methoxypsoralen is included in some cosmetic suntan preparations to enhance tanning but because of its potential phototoxicity this is considered unwise by authorities in Europe and the USA. Photosensitivity caused by 5-methoxypsoralen is sometimes known as Berloque dermatitis. 5-Methoxypsoralen is an ingredient of bergamot oil.
1. McNeely W, Goa KL. 5-Methoxypsoralen: a review of its effects in psoriasis and vitiligo. Drugs 1998; 56: 667–90.
Hypersensitivity.For mention of anaphylaxis associated with the use of 5-methoxypsoralen, see Hypersensitivity, under Adverse Effects of Methoxsalen.
Austral.: Pentaderm†; Austria: Geralen; Fr.: Psoraderm 5†; UK: Pentaderm.
Published December 29, 2018.