Pholcodine Chemical formula
Synonyms: Folcodina; Folkodiini; Folkodin; Folkodin monohydrát; Folkodinas; Pholcodinum; Pholcodinum Monohydricum. 3O-(2-Morpholinoethyl)morphine monohydrate.
Cyrillic synonym: Фолкодин.

💊 Chemical information

Chemical formula: C23H30N2O4,H2O = 416.5.
CAS — 509-67-1 (anhydrous pholcodine).
ATC — R05DA08.
ATC Vet — QR05DA08.


In Chin. and Eur..

Ph. Eur. 6.2

(Pholcodine). A white or almost white crystalline powder or colourless crystals. Sparingly soluble in water; freely soluble in alcohol and in acetone; dissolves in dilute mineral acids.

💊 Adverse Effects and Precautions

As for Dextromethorphan. Constipation, drowsiness, and skin rashes have been reported occasionally.

💊 Interactions

Use of pholcodine with alcohol or other CNS depressants may increase the effects on the CNS.

💊 Uses and Administration

Pholcodine is a centrally acting cough suppressant that has actions and uses similar to those of dextromethorphan. It is given orally in a usual dose of 5 to 10 mg three or four times daily. For children’s doses, see Administration in Children, below. The citrate has also been used. Pholcodine polistirex (a pholcodine and sulfonated diethenylbenzene-ethenylbenzene copolymer complex) has been used in modified-release preparations.

Administration in children.

Although pholcodine is licensed for use in children, over-the-counter cough and cold preparations containing cough suppressants (including pholcodine) should be used with caution and generally avoided in those under 2 years of age. The following oral doses of pholcodine are given in the BNFC for use in children:
2 to 5 years: 2 mg three times daily
5 to 12 years: 2 to 5 mg three or four times daily

💊 Preparations

BP 2008: Pholcodine Linctus; Strong Pholcodine Linctus.

Proprietary Preparations

Austral.: Actifed CC Dry; Actuss†; Duro-Tuss; Logicin Cough Suppressant†; Nyal Plus+ Dry Cough†; Ordov Dry Tickly Cough†; Pholtrate†; Tussinol; Cz.: Neocodin†; Fin.: Tu xi; Fr.: Biocalyptol; Broncorinol toux seche†; Codotussyl Toux Seche; Dimetane; Humex; Pharmakod toux seche; Respilene; Rhinathiol Toux Seche Pholcodine; Sirop des Vosges Toux Seche; Hong Kong: Duro-Tuss; Uni-Pholco; Irl.: Expulin Dry Cough; Pholcodex; Pholcolin; Malaysia: Dhacodine; Duro-Tuss; Norw.: Tu x i ; NZ: Actifed CC Dry†; Duro-Tuss; S.Afr.: Pholcolinct; Pholtex; Singapore: DuroTu s s; Spain: Trophires†; UK: Benylin Childrens Dry Coughs; Boots Dry Cough Syrup 1 Year Plus; Galenphol; Hill’s Balsam Dry Cough; Pavacol-D; Tixylix Daytime. Multi-ingredient: Austral.: Chemists Own Kiddicol; Demazin Cough & Cold; Difflam Anti-inflammatory Lozenges with Cough Suppressant; DuroTuss Cough Lozenges; Duro-Tuss Decongestant; Duro-Tuss Dry Cough Plus Nasal Decongestant; Duro-Tuss Expectorant; Phensedyl†; Tixylix Nightime; Belg.: Broncho-pectoralis Pholcodine; Eucalyptine Pholcodine; Eucalyptine Pholcodine Le Brun†; Folex†; Norhitis; Pectorhinyl; Pholco-Mereprine; Cz.: Biocalyptol S†; Fr.: Atouxx; Broncalene; Clarix; Denoral†; Hexapneumine; Isomyrtine†; Polery; Trophires; Hong Kong: Biocalyptol†; Duro-Tuss Decongestant; Duro-Tuss Expectorant; Hexapneumine; Tripe P; India: Tixylix; Irl.: Day Nurse; Expulin; Expulin Childrens Cough; Malaysia: Difflam Anti-Inflammatory Lozenges (with cough suppressant); DuroTuss Expectorant; Phensedyl Dry Cough; Promedyl Plus; Rhynacol; Russedyl Plus; Tixylix†; NZ: Difflam Cough; Duro-Tuss Cough; Duro-Tuss Expectorant; Duro-Tuss Lozenges; Phensedyl Dry Family Cough†; Tixylix; S.Afr.: Contra-Coff; Docsed; Folcofen; Pholtex Linctus; Procof; Respinol Compound; Tixylix; Singapore: 3P†; Duro-Tuss Cough Lozenges; Duro-Tuss Decongestant; Duro-Tuss Expectorant; Spain: Caltoson Balsamico; Switz.: Pecto-Baby; Phol-Tussil; Phol-Tux; Tussiplex†; UK: Boots Nightime Cough Syrup 1 Year Plus; Cough Nurse; Day & Night Nurse; Day Nurse; Expulin Childrens Cough†; Nirolex Day Cold & Flu; Nirolex Night Cold & Flu; Tixylix Cough & Cold; Tixylix Night-Time.
Published January 15, 2019.