Sodium Iotalamate

Synonyms: Iotalamate de Sodium; Iotalamato de sodico; Iotalamato de sodio; Iothalamate Sodium; Natrii Iotalamas; Sodium Iothalamate.
Cyrillic synonym: Натрий Йоталамат.

💊 Chemical information

Chemical formula: C11H8I3N2NaO4 = 635.9.
CAS — 17692-74-9; 1225-20-3.
ATC — V08AA04.
ATC Vet — QV08AA04.


Sodium iotalamate contains about 59.9% of I.


US includes only as various injections.

💊 Adverse Effects, Treatment, and Precautions

As for the amidotrizoates.

Incidence of adverse effects.

In 40 patients who underwent phlebography with 60% meglumine iotalamate minor adverse reactions were common despite the use of saline flushing and muscle contraction to clear the veins after examination.1 The commonest effect was pain at the site of injection, or in the calf and foot; 15 patients of those who had pain in the calf or foot were found to have venous thrombosis. Major complications of phlebography appear to be rare but can cause serious morbidity; examination of 200 case notes and a retrospective study involving 3060 patients revealed 4 cases of necrosis in the skin of the foot and gangrene of the foot in 2.
1. Thomas ML, MacDonald LM. Complications of ascending phlebography of the leg. BMJ 1978; ii: 317–18.

💊 Pharmacokinetics

On intravascular use the iotalamates are rapidly distributed; suitable concentrations for urography reach the urinary tract within 3 to 8 minutes of a bolus intravenous injection. Protein binding is reported to be low. The iotalamates are eliminated by the kidneys. In patients with normal renal function more than 90% of the dose injected is excreted in urine within 24 hours; an elimination half-life of about 90 minutes has been reported. Small amounts are reported to be excreted via the bile in the faeces. The iotalamates are removed by peritoneal dialysis and haemodialysis.

💊 Uses and Administration

Iotalamic acid is an ionic monomeric iodinated radiographic contrast medium with actions similar to the amidotrizoates. It may be given intravenously, intra-arterially, or by instillation into the bladder or uterus, and is used in procedures including angiography, arthrography, cholangiography, urography and hysterosalpingography. It is also used for contrast enhancement in computed tomography. Iotalamates have also been given orally or rectally for imaging of the gastrointestinal tract. Iotalamic acid is usually available as solutions containing up to 66.8% of sodium iotalamate or up to 60% of meglumine iotalamate. The dose and strength used vary according to the procedure and route. A mixture of the two salts has been given to minimise adverse effects.

💊 Preparations

USP 31: Iothalamate Meglumine and Iothalamate Sodium Injection; Iothalamate Meglumine Injection; Iothalamate Sodium Injection.

Proprietary Preparations

Arg.: Conray; Cysto-Conray; Austral.: Conray 280; Canad.: Conray; Cysto-Conray; Ger.: Conray 30†; Conray 60†; Ital.: Conray†; UK: Conray; USA: Conray; Cysto-Conray.
Published December 15, 2018.