Obidoxime Chloride

(USAN, rINN)
Obidoxime Chloride Chemical formula
Synonyms: Cloruro de obidoxima; LüH6; Obidoxime, Chlorure d’; Obidoximi Chloridum. 1,1′-[Oxybis(methylene)]bis[4-(hydroxyimino)methyl]pyridinium dichloride.
Cyrillic synonym: Обидоксима Хлорид.

💊 Chemical information

Chemical formula: C14H16Cl2N4O3 = 359.2.
CAS — 7683-36-5 (obidoxime); 114-90-9 (obidoxime chloride).
ATC — V03AB13.
ATC Vet — QV03AB13.

💊 Profile

Obidoxime chloride is a cholinesterase reactivator with similar actions and uses to pralidoxime. It is given with atropine in the treatment of organophosphorus poisoning in a usual initial dose of 250 mg (4 mg/kg) by slow intravenous injection. This may be followed by intravenous infusion of 750 mg over 24 hours, continued until the concentration of organophosphate is below critical levels; alternatively, repeated doses of 4 to 8 mg/kg may be given at intervals of 2 to 4 hours. It has also been given by intramuscular injection.
1. Thiermann H, et al. Cholinesterase status, pharmacokinetics and laboratory findings during obidoxime therapy in organophosphate poisoned patients. Hum Exp Toxicol 1997; 16: 473–80.

💊 Preparations

Proprietary Preparations

Austria: Toxogonin; Chile: Toxogonin; Cz.: Toxogonin; Ger.: Toxogonin; Neth.: Toxogonin; S.Afr.: Toxogonin; Swed.: Toxogonin; Switz.: To x o g onine.
Published December 10, 2018.