Synonyms: Hidrocloruro de nalorfina; Nalorphine, Chlorhydrate de; Nalorphini Hydrochloridum; Nalorphinium Chloride.
Cyrillic synonym: Налорфина Гидрохлорид.
💊 Chemical information
Chemical formula: C19H21NO3,HCl = 347.8.
CAS — 57-29-4.
ATC — V03AB02.
ATC Vet — QV03AB02.
USP 31(Nalorphine Hydrochloride). Store in airtight containers at a temperature of 25°, excursions permitted between 15° and 30°. Protect from light.
💊 Adverse Effects and Precautions
As for Naloxone (below). Nalorphine also has some opioid agonist properties and adverse effects such as drowsiness, respiratory depression, miosis, dysphoria, and lethargy may occur if it is given to patients who have not received opioids.
💊 Uses and Administration
Nalorphine is an opioid antagonist with properties similar to those of naloxone (below); in addition it also possesses some agonist properties. It has been used as the hydrobromide or hydrochloride in the treatment of opioid-induced respiratory depression; it reverses severe opioid-induced respiratory depression but may exacerbate respiratory depression such as that induced by alcohol or other non-opioid central depressants.
USP 31: Nalorphine Hydrochloride Injection.
Published December 07, 2018.