Lanthanum Carbonate

(USAN)

💊 Chemical information

Lanthanum carbonate (2:3) hydrate.
Chemical formula: La2(CO3)3,xH2O = 457.8 (anhydrous lanthanum carbonate).
CAS — 54451-24-0.
ATC — V03AE03.
ATC Vet — QV03AE03.

💊 Adverse Effects and Precautions

The most common adverse effects with lanthanum carbonate are gastrointestinal disturbances, including nausea, vomiting, constipation, diarrhoea, dyspepsia, and abdominal pain. Only small amounts of lanthanum are absorbed from the gastrointestinal tract but some accumulation of lanthanum in bone has been reported; the clinical significance of this is unknown. Ingestion of lanthanum carbonate may produce a radio-opaque appearance on abdominal radiography.

💊 Uses and Administration

Lanthanum carbonate is a phosphate binder used for hyperphosphataemia in patients with chronic renal failure. It is given orally as the hydrate, but doses are expressed in terms of elemental lanthanum. The usual initial daily dose is 0.75 to 2.25 g of elemental lanthanum, given in divided doses with meals. The dose should be adjusted every 2 to 3 weeks until an acceptable serum-phosphate concentration is achieved; the usual maintenance dose is 1.5 to 3 g daily in divided doses, but up to 3.75 g daily has been given. The tablets should be chewed thoroughly before swallowing.
1. Swainston Harrison T, Scott LJ. Lanthanum carbonate. Drugs 2004; 64: 985–96
2. Joy MS, et al. Lanthanum carbonate. Ann Pharmacother 2006; 40: 234–40.

💊 Preparations

Proprietary Preparations

Austral.: Fosrenol; Cz.: Fosrenol; Fr.: Fosrenol; Gr.: Fosrenol; Irl.: Foznol; Port.: Fosrenol; Swed.: Fosrenol; UK: Fosrenol; USA: Fosrenol.
Published November 19, 2018.