Synonyms: Carboxypeptidase G 2 ; Glucarpidasa; Glucarpidasum.
Cyrillic synonym: Глюкарпидаз.

Chemical information

CAS — 9074-87-7.
ATC — V03AF09.
ATC Vet — QV03AF09.


Glucarpidase is a recombinant glutamate carboxypeptidase that hydrolyses methotrexate to inactive metabolites; it is under investigation for the management of methotrexate toxicity.
1. Widemann BC, et al. Carboxypeptidase-G2, thymidine, and leucovorin rescue in cancer patients with methotrexate-induced renal dysfunction. J Clin Oncol 1997; 15: 2125–34
2. Widemann BC, et al. Treatment of accidental intrathecal methotrexate overdose with intrathecal carboxypeptidase G2. J Natl Cancer Inst 2004; 96: 1557–9
3. Buchen S, et al. Carboxypeptidase G2 rescue in patients with methotrexate intoxication and renal failure. Br J Cancer 2005; 92: 480–7.
Published November 16, 2018.