Ammonium Tetrathiomolybdate

(BAN, USAN, rINN)
Ammonium Tetrathiomolybdate Chemical formula

Chemical information

Tetratiomolibdato de amonio.
Chemical formula: (NH4)2MoS4 = 260.3.
CAS — 15060-55-6.

Profile

Ammonium tetrathiomolybdate is a chelator that aids the elimination of copper from the body. It is under investigation in the treatment of

Wilson’s disease.Wilson’s disease.

Ammonium tetrathiomolybdate forms a complex with protein and copper. When it is taken with food it blocks the intestinal absorption of copper, and when given between meals it combines with albumin- and caeruloplasminbound copper. Ammonium tetrathiomolybdate is under investigation for the initial reduction of copper levels in patients with Wilson’s disease; it may be particularly suitable for patients with neurological symptoms.1 Bone marrow depression1,2and raised liver enzymes1 have been reported; both have responded to temporary withdrawal or dose reduction.
1. Brewer GJ, et al. Treatment of Wilson disease with ammonium tetrathiomolybdate III: initial therapy in a total of 55 neurologically affected patients and follow-up with zinc therapy. Arch Neurol 2003; 60: 379–85
2. Harper PL, Walshe JM. Reversible pancytopenia secondary to treatment with tetrathiomolybdate. Br J Haematol 1986; 64: 851–3.
Published October 13, 2018.