Rauwolfia Serpentina

(USAN, rINNM)

💊 Chemical information

Chotachand; Rauvolfia; Rauwolfia; Rauwolfiae Radix; Rauwolfiawurzel.
CAS — 8063-17-0 (rauwolfia).
ATC — C02AA04.

Pharmacopoeias.

In Ger. and US.

USP 31

(Rauwolfia Serpentina). The dried roots of Rauwolfia serpentina (Apocynaceae). It contains not less than 0.15% of reserpine-rescinnamine group alkaloids calculated as reserpine. Store at 15° to 30° in a dry place.

💊 Profile

Rauwolfia serpentina contains numerous alkaloids, the most active as hypotensive agents being the ester alkaloids, reserpine and rescinnamine. Other alkaloids present have structures related to reserpic acid, but are not esterified, and include ajmaline (rauwolfine), ajmalinine, ajmalicine, isoajmaline (isorauwolfine), serpentine, rauwolfinine, and sarpagine. The actions of rauwolfia serpentina are those of its alkaloids and it has been used for the same purposes as reserpine. It has been given orally as the powdered whole root. Rauwolfia vomitoria has also been used. A crude form of rauwolfia serpentina has been used in India for centuries as preparations such as Sarpagandha, in the treatment of insomnia and certain forms of mental illness.

💊 Preparations

USP 31: Rauwolfia Serpentina Tablets. Proprietary PreparationsMulti-ingredient: Ger.: Hyperforat-forte†; Rus.: Speman Forte (Спеман Форте); Spain: Rulun; USA: Rauzide†.
Published May 08, 2019.