Potassium Canrenoate

(BANM, rINN)
Potassium Canrenoate Chemical formula
Synonyms: Aldadiene Potassium; Canrénoate de Potassium; Canrenoate Potassium kanrenoaatti; Kaliumkanrenoat; MF-465a; SC-14266. Potassium 17-hydroxy-3-oxo-17
Cyrillic synonym: Калия Канреноат.

💊 Chemical information

Chemical formula: C22H29KO4 = 396.6.
CAS — 4138-96-9 (canrenoic acid); 2181-04-6 (potassium canrenoate).
ATC — C03 DA02.
ATC Vet — QC0 3DA02.

Pharmacopoeias.

In Jpn.

💊 Adverse Effects and Precautions

As for Spironolactone. Irritation or pain may occur at the site of injection.

Effects on endocrine function.

A lower incidence of gynaecomastia has been reported in patients with hepatic cirrhosis and ascites during use of potassium canrenoate than with equivalent doses of spironolactone,1 and spironolactone-induced gynaecomastia disappeared when spironolactone was replaced by potassium canrenoate in a patient with hyperaldosteronism.2 This suggests that metabolites other than canrenone (a common metabolite of both canrenoate and spironolactone thought to be responsible for their activity) or possibly spironolactone itself may be responsible for the anti-androgenic effects of spironolactone.3,4
1. Bellati G, Idéo G. Gynaecomastia after spironolactone and potassium canrenoate. Lancet 1986; i: 626
2. Dupont A. Disappearance of spironolactone-induced gynaecomastia during treatment with potassium canrenoate. Lancet 1985; ii: 731
3. Gardiner P. Spironolactone and potassium canrenoate metabolism. Lancet 1985; ii: 1432
4. Overdiek JWPM, Merkus FWHM. Spironolactone metabolism and gynaecomastia. Lancet 1986; i: 1103.

💊 Interactions

💊 Uses and Administration

Potassium canrenoate is a potassium-sparing diuretic with actions and uses similar to those of spironolactone. Canrenone is a metabolite common to both drugs, but its contribution to the pharmacological action is unclear. Potassium canrenoate is used in the treatment of refractory oedema associated with heart failure or hepatic disease when an injectable aldosterone antagonist is required. It may be given in doses of 200 to 400 mg daily, increasing to 800 mg daily in exceptional cases; it is given by slow intravenous injection over a period of 2 to 3 minutes for each 200 mg or by intravenous infusion in glucose 5% or sodium chloride 0.9%.

💊 Preparations

Proprietary Preparations

Austria: Aldactone; Belg.: Canrenol; Soldactone; Cz.: Aldactone; Canrenol†; Fr.: Soludactone; Ger.: Aldactone; Kalium-Can; Hung.: Aldactone†; Ital.: Dikantal; Diurek; Kanrenol; Luvion; Venactone†; Neth.: Soldactone; Norw.: Soldactone†; Pol.: Aldactone; Switz.: Soldactone. Multi-ingredient: Ital.: Kadiur.
Published May 08, 2019.