Lamifiban

(USAN, rINN)
Lamifiban Chemical formula
Synonyms: Lamifibán; Lamifibanum; Ro44-9883; Ro-44-9883/000. ({1-[N(p-Amidinobenzoyl)
Cyrillic synonym: Ламифибан.

Chemical information

Chemical formula: C24H28N4O6 = 468.5.
CAS — 144412-49-7 (lamifiban); 243835-65-6 (lamifiban hydrochloride).

Profile

Lamifiban is a glycoprotein IIb/IIIa-receptor antagonist. It has been investigated as an antiplatelet drug given intravenously for the management of thromboembolic disorders, such as unstable angina and myocardial infarction.
1. Théroux P, et al. Platelet membrane receptor glycoprotein IIb/IIIa antagonism in unstable angina: the Canadian Lamifiban Study. Circulation 1996; 94: 899–905
2. The PARAGON Investigators. International, randomized, controlled trial of lamifiban (a platelet glycoprotein IIb/IIIa inhibitor), heparin, or both in unstable angina. Circulation 1998; 97: 2386–95
3. The PARADIGM Investigators. Combining thrombolysis with the platelet glycoprotein IIb/IIIa inhibitor lamifiban: results of the Platelet Aggregation Receptor Antagonist Dose Investigation and Reperfusion Gain in Myocardial Infarction (PARADIGM) trial. J Am Coll Cardiol 1998; 32: 2003–10
4. Global Organization Network (PARAGON)-B Investigators. Randomized, placebo-controlled trial of titrated intravenous lamifiban for acute coronary syndromes. Circulation 2002; 105: 316–21.
Published May 08, 2019.