Hydroflumethiazide

(BAN, rINN)
Hydroflumethiazide Chemical formula
Synonyms: Hidroflumetiazida; Hydrofluméthiazide; Hydroflumethiazidum; Hydroflumetiatsidi; Hydroflumetiazid; Trifluoromethylhydrothiazide. 3,4-Dihydro-6-trifluoromethyl-2H-1,2,4-benzothiadiazine7-sulphonamide 1,1-dioxide.
Cyrillic synonym: Гидрофлуметиазид.

💊 Chemical information

Chemical formula: C8H8F3N3O4S2 = 331.3.
CAS — 135-09-1.
ATC — C03AA02.
ATC Vet — QC03AA02.

Pharmacopoeias.

In Br. and US.

BP 2008

(Hydroflumethiazide). White or almost white, odourless or almost odourless, glistening crystals or crystalline powder. Practically insoluble in water; soluble in alcohol; practically insoluble in chloroform and in ether.

USP 31

(Hydroflumethiazide). A white to cream-coloured, odourless, finely divided crystalline powder. Very slightly soluble in water and in chloroform; soluble 1 in 39 of alcohol and 1 in 2500 of ether; freely soluble in acetone. A 1% dispersion in water has a pH of 4.5 to 7.5. Store in airtight containers.

💊 Adverse Effects, Treatment, and Precautions

As for Hydrochlorothiazide.

💊 Interactions

As for Hydrochlorothiazide.

💊 Pharmacokinetics

Hydroflumethiazide is incompletely but fairly rapidly absorbed from the gastrointestinal tract. It is reported to have a beta-phase biological half-life of about 17 hours and a metabolite with a longer half-life that is extensively bound to red blood cells. Hydroflumethiazide is excreted in the urine; its metabolite has also been detected in the urine.
1. Brørs O, et al. Pharmacokinetics of a single dose of hydroflumethiazide in health and in cardiac failure. Eur J Clin Pharmacol 1978; 14: 29–37.

💊 Uses and Administration

Hydroflumethiazide is a thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. It is given orally for oedema, including that associated with heart failure, and for hypertension. Diuresis begins about 2 hours after an oral dose and has been reported to last for up to 24 hours. In the treatment of oedema the usual initial dose is 50 to 100 mg daily, in one or two divided doses, reduced to a dose of 25 to 50 mg on alternate days or intermittently. Doses of up to 200 mg daily may be required by some patients. In the treatment of hypertension the usual dose is 25 to 50 mg daily either alone, or with other antihypertensives. An initial dose of 12.5 mg has been used. An initial dose for children is 1 mg/kg daily, reduced for maintenance.

💊 Preparations

BP 2008: Hydroflumethiazide Tablets; USP 31: Hydroflumethiazide Tablets.

Proprietary Preparations

USA: Diucardin†; Saluron. Multi-ingredient: Irl.: Aldactide; S.Afr.: Protensin-M; UK: Aldactide; USA: Salutensin†.
Published April 13, 2019.