von Willebrand Factor

(BAN, USAN, rINN)

💊 Chemical information

Facteur Willebrand humain (human von Willebrand factor); Factor humanus von Willebrandi (human von Willebrand factor); Factor VIII-related Antigen; vWF.

Pharmacopoeias.

In Eur..

Ph. Eur. 6.2

(Human von Willebrand Factor). A preparation of a plasma protein fraction that contains the glycoprotein von Willebrand factor with varying amounts of coagulation factor VIII, depending on the method of preparation. It is prepared from human plasma obtained from blood from healthy donors: the plasma is tested for the absence of hepatitis B surface antigen and antibodies against HIV-1 and HIV-2 and hepatitis C virus. When reconstituted as stated on the label, the potency is not less than 20 international units of von Willebrand factor per mL. It is a white or pale yellow, hygroscopic powder or friable solid. Store in airtight containers. Protect from light.

💊 Profile

von Willebrand factor is used in the treatment and prophylaxis of bleeding in von Willebrand’s disease, usually when desmopressin is ineffective or contra-indicated. It is generally contained in plasma concentrate preparations with factor VIII, but highly purified preparations that contain very little factor VIII are also available in some countries. Dosage depends on the extent and source of bleeding. Hypersensitivity reactions may occur rarely, and as for other plasma-derived preparations, the risk of transmission of infective agents cannot be totally excluded.
1. Smith MP, et al. Continuous infusion therapy with very high purity von Willebrand factor concentrate in patients with severe von Willebrand disease. Blood Coag Fibrinol 1997; 8: 6–12
2. Goudemand J, et al. Clinical management of patients with von Willebrand’s disease with a VHP vWF concentrate: the French experience. Haemophilia 1998; 4 (suppl 3): 48–52.

💊 Preparations

Proprietary Preparations

Fr.: Wilfactin; Wilstart; Gr.: Wilfactin.
Published October 07, 2018.