Leucocytes

(BAN, USAN, rINN)

💊 Chemical information

Leucocitos.

Description.

Preparations of leucocytes contain granulocytes with a variable content of red blood cells, lymphocytes, and platelets. Depending on the method of collection they may also contain dextran or hetastarch.

💊 Adverse Effects and Precautions

Leucocyte transfusions may cause severe transfusion reactions and fever. As with other blood products, there is a risk of transmission of infection. Severe lung reactions, including fluid overload with pulmonary oedema, are a particular problem in patients with active pulmonary infections. Red blood cell compatibility testing is necessary because of the content of red blood cells. Graft-versus-host disease may occur in immunosuppressed recipients, and can be avoided by irradiating the product before it is given.

💊 Uses and Administration

Transfusion of leucocytes has been used in patients with severe granulocytopenia and infection which has not been controlled by treatment with appropriate antimicrobials. Transfusion of 1 × 1010 granulocytes once or twice daily has been suggested as an effective dose. Daily transfusions for at least 3 to 4 days are usually advised. Hydrocortisone and chlorphenamine may be given intravenously before transfusion to reduce the severity of adverse reactions.
1. Brozović B, et al. Platelet and granulocyte transfusions. In: Contreras M, ed. ABC of transfusion. 3rd ed. London: BMJ Books, 1998: 17–22
2. Yeghen T, Devereux S. Granulocyte transfusion: a review. Vo x Sang 2001; 81: 87–92
3. Hubel K, Engert A. Granulocyte transfusion therapy for treatment of infections after cytotoxic chemotherapy. Onkologie 2003; 26: 73–9
4. Briones MA, et al. Granulocyte transfusion: revisited. Curr Hematol Rep 2003; 2: 522–7.

💊 Preparations

Proprietary Preparations

Cz.: Immodin; Ger.: LeukoNorm.
Published December 09, 2018.